Arthritis, Psoriatic | Joint tenderness | Joint swelling
Item
patients with active psoriatic arthritis (3 tender and swollen joints) meeting caspar study group criteria
boolean
C0003872 (UMLS CUI [1])
C0240094 (UMLS CUI [2])
C0152031 (UMLS CUI [3])
Body mass index
Item
bmi > 35 kg/m2
boolean
C1305855 (UMLS CUI [1])
DIABETES MELLITUS UNCONTROLLED | Glycosylated hemoglobin A
Item
uncontrolled diabetes, hba1c > 10.5%
boolean
C0743131 (UMLS CUI [1])
C0019018 (UMLS CUI [2])
Biological treatment Inflammatory disorder
Item
current biological treatment for any inflammatory disorder within the past three months
boolean
C1531518 (UMLS CUI [1,1])
C1290884 (UMLS CUI [1,2])
Renal dysfunction | Estimated Glomerular Filtration Rate | Macroalbuminuria
Item
renal dysfunction (egfr < 50 ml/min/1.73m or macroalbuminuria >300mg)
boolean
C3279454 (UMLS CUI [1])
C3811844 (UMLS CUI [2])
C1654921 (UMLS CUI [3])
Liver Dysfunction | Aspartate aminotransferase measurement | Alanine aminotransferase measurement | Bilirubin, total measurement
Item
hepatic dysfunction (ast (aspartate aminotransferase), alt (alanine aminotransferase), total bilirubin > 3 times upper limit of normal)
boolean
C0086565 (UMLS CUI [1])
C0201899 (UMLS CUI [2])
C0201836 (UMLS CUI [3])
C0201913 (UMLS CUI [4])
Pancreatitis | Medullary carcinoma of thyroid | C-cell hyperplasia | Multiple Endocrine Neoplasia Type 2a
Item
history of pancreatitis or personal or family history of medullary thyroid cancer, c-cell hyperplasia, or men-2 syndrome
boolean
C0030305 (UMLS CUI [1])
C0238462 (UMLS CUI [2])
C0342190 (UMLS CUI [3])
C0025268 (UMLS CUI [4])
Pregnancy | Breast Feeding
Item
current pregnancy or current breast feeding
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Dipeptidyl Peptidase-4 Inhibitor | GLP-1 Receptor Agonist | Washout
Item
use of dpp-4 (dipeptidyl peptidase-4 inhibitor) or glp-1 receptor agonist within 2 months (washout is permitted)
boolean
C3537225 (UMLS CUI [1])
C2917359 (UMLS CUI [2])
C1710661 (UMLS CUI [3])
Substance Dependence
Item
drug or alcohol dependence
boolean
C0038580 (UMLS CUI [1])
TACHYCARDIA REST | Cardiac conduction abnormalities Associated with Tachycardia
Item
resting tachycardia > 100 bpm or conduction abnormalities associated with tachycardia
boolean
C0749248 (UMLS CUI [1])
C1842820 (UMLS CUI [2,1])
C0332281 (UMLS CUI [2,2])
C0039231 (UMLS CUI [2,3])
Study Subject Participation Status
Item
current enrollment in any other clinical trial
boolean
C2348568 (UMLS CUI [1])
Gastroparesis Symptomatic
Item
symptomatic gastroparesis
boolean
C0152020 (UMLS CUI [1,1])
C0231220 (UMLS CUI [1,2])
concomitant conditions Serious
Item
concomitant serious medical conditions
boolean
C0243086 (UMLS CUI [1,1])
C0205404 (UMLS CUI [1,2])
Therapeutic procedure Arthritis, Psoriatic | Pharmaceutical Preparations Dosage Stable status | Methotrexate | leflunomide | Anti-Inflammatory Agents, Non-Steroidal
Item
all medication for the treatment of psoriatic arthritis such as mtx (methotrexate) < 25 mg, lfn (leflunomide) < 20 mg, and nsaids (non-steroidal anti-inflammatory drugs) will have been used at stable doses for at least 4 weeks, having been initiated at least 3 months prior to study start (8 weeks before screening, 4 weeks before baseline) for mtx and lfn and at least 4 weeks for nsaids
boolean
C0087111 (UMLS CUI [1,1])
C0003872 (UMLS CUI [1,2])
C0013227 (UMLS CUI [2,1])
C0178602 (UMLS CUI [2,2])
C0205360 (UMLS CUI [2,3])
C0025677 (UMLS CUI [3])
C0063041 (UMLS CUI [4])
C0003211 (UMLS CUI [5])