Multiple Sclerosis, Relapsing-Remitting | Multiple Sclerosis
Item
relapsing remitting multiple sclerosis according to poser criteria (cdms or ldms) or multiple sclerosis according to mcdonald criteria
boolean
C0751967 (UMLS CUI [1])
C0026769 (UMLS CUI [2])
EDSS
Item
disability equivalent to edss of 6.0 or less
boolean
C0451246 (UMLS CUI [1])
Relapse Quantity
Item
clinical activity defined as at least one relapse rate within the last 12 months
boolean
C0277556 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
Neutralizing Antibody titer measurement | Interferon-beta Injection
Item
nab titre >20 (measured at least 48 hours after last interferon-beta injection
boolean
C0475463 (UMLS CUI [1,1])
C0474643 (UMLS CUI [1,2])
C0015980 (UMLS CUI [2,1])
C1828121 (UMLS CUI [2,2])
interferon beta-1b Subcutaneous | Interferon beta-1a Subcutaneous | Rebif Subcutaneous
Item
has been treated with subcutaneously administered interferon-beta-1b or interferon-beta-1a (rebif) for at least 24 hours before enrollment
boolean
C0244713 (UMLS CUI [1,1])
C1522438 (UMLS CUI [1,2])
C0254119 (UMLS CUI [2,1])
C1522438 (UMLS CUI [2,2])
C0752980 (UMLS CUI [3,1])
C1522438 (UMLS CUI [3,2])
Condition Causing Symptoms Multiple Sclerosis Similar
Item
any condition that might give rise to similar symptoms as ms
boolean
C0348080 (UMLS CUI [1,1])
C0678227 (UMLS CUI [1,2])
C1457887 (UMLS CUI [1,3])
C0026769 (UMLS CUI [1,4])
C2348205 (UMLS CUI [1,5])
Immunomodulation | Interferon beta-1a | interferon beta-1b | Therapeutic immunosuppression
Item
immunomodulatory therapy other than interferon-beta-1a or interferon-beta-1b or any immunosuppressive treatment six months prior to inclusion into the trial
boolean
C1963758 (UMLS CUI [1])
C0254119 (UMLS CUI [2])
C0244713 (UMLS CUI [3])
C0021079 (UMLS CUI [4])
Glucocorticoids | Corticotropin
Item
treatment with glucocorticoids or acth less than one month prior to inclusion into the trial
boolean
C0017710 (UMLS CUI [1])
C0001655 (UMLS CUI [2])
Major Depressive Disorder
Item
history of major depression
boolean
C1269683 (UMLS CUI [1])
Substance Dependence
Item
alcohol or drug dependency
boolean
C0038580 (UMLS CUI [1])
Heart failure | Cardiomyopathy | Cardiac Arrhythmia Significant | Myocardial Ischemia Unstable New York Heart Association Classification | Myocardial Ischemia Advanced New York Heart Association Classification
Item
cardiac insufficiency, cardiomyopathy, significant cardiac dysrhythmia, unstable or advanced ischemic heart disease (nyha iii or iv)
boolean
C0018801 (UMLS CUI [1])
C0878544 (UMLS CUI [2])
C0003811 (UMLS CUI [3,1])
C0750502 (UMLS CUI [3,2])
C0151744 (UMLS CUI [4,1])
C0443343 (UMLS CUI [4,2])
C1275491 (UMLS CUI [4,3])
C0151744 (UMLS CUI [5,1])
C0205179 (UMLS CUI [5,2])
C1275491 (UMLS CUI [5,3])
Hypertensive disease | Blood Pressure
Item
hypertension (bp > 180/110 mmhg)
boolean
C0020538 (UMLS CUI [1])
C0005823 (UMLS CUI [2])
Renal Insufficiency | Creatinine measurement, serum
Item
renal insufficiency defined as serum creatinine > 1.5 times the upper normal reference limit
boolean
C1565489 (UMLS CUI [1])
C0201976 (UMLS CUI [2])
Systemic disease Affecting patient safety | Systemic disease Limiting Compliance behavior | Systemic disease Affecting Evaluation Disability
Item
any systemic disease that can influence the patient's safety and compliance, or the evaluation of the disability
boolean
C0442893 (UMLS CUI [1,1])
C0392760 (UMLS CUI [1,2])
C1113679 (UMLS CUI [1,3])
C0442893 (UMLS CUI [2,1])
C0439801 (UMLS CUI [2,2])
C1321605 (UMLS CUI [2,3])
C0442893 (UMLS CUI [3,1])
C0392760 (UMLS CUI [3,2])
C1261322 (UMLS CUI [3,3])
C0231170 (UMLS CUI [3,4])
Gastrointestinal ulcer | Gastritis | Dyspepsia
Item
gastro-intestinal ulcers, gastritis, or dyspepsia
boolean
C0237938 (UMLS CUI [1])
C0017152 (UMLS CUI [2])
C0013395 (UMLS CUI [3])
Pregnancy | Breast Feeding | Pregnancy Possible | Postmenopausal state | Female Sterilization | Sexual Abstinence | Contraceptive methods
Item
women who are pregnant, breast-feeding or have the possibility for pregnancy during the trial. to avoid pregnancy, women have to be postmenopausal, surgical sterile, sexually inactive or practice reliable contraceptives
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
C0032961 (UMLS CUI [3,1])
C0332149 (UMLS CUI [3,2])
C0232970 (UMLS CUI [4])
C0015787 (UMLS CUI [5])
C0036899 (UMLS CUI [6])
C0700589 (UMLS CUI [7])