Recurrent adult acute myeloid leukemia | Acute Myelocytic Leukemia refractory | Myelodysplastic syndrome High risk
Item
histologically or cytologically confirmed relapsed or refractory acute myeloid leukemia (aml) or high-risk myelodysplastic syndrome.
boolean
C0278780 (UMLS CUI [1])
C0023467 (UMLS CUI [2,1])
C0205269 (UMLS CUI [2,2])
C3463824 (UMLS CUI [3,1])
C0332167 (UMLS CUI [3,2])
Zubrod Performance Status
Item
performance status 0-2 (zubrod scale).
boolean
C3714786 (UMLS CUI [1])
Creatinine measurement, serum | Creatinine clearance measurement
Item
serum creatinine equal or less than 1.3 mg/dl or creatinine clearance > 40 ml/min.
boolean
C0201976 (UMLS CUI [1])
C0373595 (UMLS CUI [2])
Serum total bilirubin measurement
Item
bilirubin </= 2 mg/dl; serum glutamic oxaloacetic transaminase (sgot) or serum glutamic pyruvic transaminase (sgpt) </= 3 times the upper limit of normal (uln) for the reference lab unless due to leukemia or congenital hemolytic disorder (for bilirubin).
boolean
C1278039 (UMLS CUI [1])
Informed Consent
Item
written informed consent.
boolean
C0021430 (UMLS CUI [1])
Life-threatening infection untreated | Life-threatening infection Uncontrolled
Item
no untreated or uncontrolled life-threatening infection.
boolean
C1859430 (UMLS CUI [1,1])
C0332155 (UMLS CUI [1,2])
C1859430 (UMLS CUI [2,1])
C0205318 (UMLS CUI [2,2])
Intolerance to oxaliplatin | Intolerance to fludarabine | Intolerance to Cytarabine
Item
no oxaliplatin, fludarabine, or cytarabine intolerance.
boolean
C1744706 (UMLS CUI [1,1])
C0069717 (UMLS CUI [1,2])
C1744706 (UMLS CUI [2,1])
C0059985 (UMLS CUI [2,2])
C1744706 (UMLS CUI [3,1])
C0010711 (UMLS CUI [3,2])
Pregnancy | Breast Feeding | Childbearing Potential Contraceptive methods | Postmenopausal state Duration Contraceptive methods | Gender Contraceptive methods
Item
no pregnancy or lactation. female patients of childbearing potential (including those < 1 year post-menopausal) and male patients must agree to use contraception.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
C3831118 (UMLS CUI [3,1])
C0700589 (UMLS CUI [3,2])
C0232970 (UMLS CUI [4,1])
C0449238 (UMLS CUI [4,2])
C0700589 (UMLS CUI [4,3])
C0079399 (UMLS CUI [5,1])
C0700589 (UMLS CUI [5,2])
Chemotherapy | Therapeutic radiology procedure | Hydroxyurea pre treatment allowed | Disease Proliferating Rapidly
Item
no chemotherapy or radiation therapy within 4 weeks of study entry. hydroxyurea is allowed prior to starting therapy in the setting of rapidly proliferating disease.
boolean
C0392920 (UMLS CUI [1])
C1522449 (UMLS CUI [2])
C0020402 (UMLS CUI [3,1])
C2709094 (UMLS CUI [3,2])
C0683607 (UMLS CUI [3,3])
C0012634 (UMLS CUI [4,1])
C1514485 (UMLS CUI [4,2])
C0456962 (UMLS CUI [4,3])
Medical condition Interferes with Informed Consent | Medical condition Interferes with Compliance behavior | Medical condition Interferes with Study Subject Participation Status | Medical condition Interferes with Interpretation Research results | Mental disorder | Substance Use Disorders
Item
no other medical condition, including mental illness or substance abuse, deemed by the investigator to be likely to interfere with a patient's ability to sign informed consent or cooperate and participate in the study or to interfere with the interpretation of the results.
boolean
C3843040 (UMLS CUI [1,1])
C0521102 (UMLS CUI [1,2])
C0021430 (UMLS CUI [1,3])
C3843040 (UMLS CUI [2,1])
C0521102 (UMLS CUI [2,2])
C1321605 (UMLS CUI [2,3])
C3843040 (UMLS CUI [3,1])
C0521102 (UMLS CUI [3,2])
C2348568 (UMLS CUI [3,3])
C3843040 (UMLS CUI [4,1])
C0521102 (UMLS CUI [4,2])
C0459471 (UMLS CUI [4,3])
C0683954 (UMLS CUI [4,4])
C0004936 (UMLS CUI [5])
C0038586 (UMLS CUI [6])