Inclusion Criteria
age >=18 Years
boolean
Men >/= 18 years of age with histologically confirmed prostate cancer
Radiographic evidence of at least one bone metastasis
Failure of at least one hormonal therapy as evidenced by a rising PSA
Serum testosterone level of <50 ng/dL
ECOG
Adequate organ function
Exclusion Criteria
Current or prior IV bisphosphonate administration
Current or prior oral bisphosphonates for bone mets
life expectancy of less than 6 months