Age | Philadelphia chromosome positive CML Chronic phase | Cytogenetic Complete Response failed | Imatinib Dosage
Item
men and women ≥18 years diagnosed with chronic phase philadelphia chromosome positive (cp ph+) cml who have failed to achieve ccyr after 3-18 months of therapy with imatinib 400 mg
boolean
C0001779 (UMLS CUI [1])
C0279543 (UMLS CUI [2,1])
C0457343 (UMLS CUI [2,2])
C4050364 (UMLS CUI [3,1])
C0231175 (UMLS CUI [3,2])
C0935989 (UMLS CUI [4,1])
C0178602 (UMLS CUI [4,2])
Imatinib Dosage
Item
treatment initiation with imatinib 400 mg within 6 months of initial cml diagnosis
boolean
C0935989 (UMLS CUI [1,1])
C0178602 (UMLS CUI [1,2])
Imatinib High dose chronic
Item
able to tolerate chronic administration of imatinib at the highest dose (400-600 mg) the subject has received in the past
boolean
C0935989 (UMLS CUI [1,1])
C0444956 (UMLS CUI [1,2])
C0205191 (UMLS CUI [1,3])
ECOG performance status
Item
eastern cooperative oncology group performance status (ecog ps) 0-2
boolean
C1520224 (UMLS CUI [1])
Liver function | Renal function
Item
adequate hepatic and renal function
boolean
C0232741 (UMLS CUI [1])
C0232804 (UMLS CUI [2])
Autologous hematopoietic stem cell transplant | Allogeneic hematopoietic stem cell transplant
Item
eligible and willing to undergo immediate autologous/allogeneic stem cell transplant
boolean
C2193200 (UMLS CUI [1])
C4255274 (UMLS CUI [2])
Leukemia, Myeloid, Accelerated Phase | Chronic myelogenous leukemia with crisis of blast cells
Item
previous diagnosis of accelerated/blast crisis cml
boolean
C0023472 (UMLS CUI [1])
C2861579 (UMLS CUI [2])
Clonal Evolution Cells Philadelphia chromosome positive | Observation Metaphase Quantity
Item
subjects with clonal evolution in ph+ cells observed in ≥2 metaphases
boolean
C1516669 (UMLS CUI [1,1])
C0007634 (UMLS CUI [1,2])
C0856536 (UMLS CUI [1,3])
C1964257 (UMLS CUI [2,1])
C1621812 (UMLS CUI [2,2])
C1265611 (UMLS CUI [2,3])
T315I mutation
Item
previous documentation of t315i mutation
boolean
C3889036 (UMLS CUI [1])
Cardiovascular Disease Uncontrolled
Item
uncontrolled or significant cardiovascular disease
boolean
C0007222 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])
Disease Serious Uncontrolled | Communicable Disease Serious Uncontrolled
Item
serious uncontrolled medical disorder/active infection
boolean
C0012634 (UMLS CUI [1,1])
C0205404 (UMLS CUI [1,2])
C0205318 (UMLS CUI [1,3])
C0009450 (UMLS CUI [2,1])
C0205404 (UMLS CUI [2,2])
C0205318 (UMLS CUI [2,3])
Blood Coagulation Disorder Independent of CML
Item
history of significant bleeding disorder unrelated to cml
boolean
C0005779 (UMLS CUI [1,1])
C0332291 (UMLS CUI [1,2])
C0023473 (UMLS CUI [1,3])
Intolerance to imatinib
Item
intolerance to imatinib ≥400 mg
boolean
C1744706 (UMLS CUI [1,1])
C0935989 (UMLS CUI [1,2])
Cancer Other | Exception CML
Item
concurrent malignancies other than cml
boolean
C1707251 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C0023473 (UMLS CUI [2,2])