Multiple Sclerosis, Relapsing-Remitting
Item
subjects with a diagnosis of rrms according to the mc donald criteria(2005)
boolean
C0751967 (UMLS CUI [1])
Age
Item
18 to 60 years of age
boolean
C0001779 (UMLS CUI [1])
EDSS
Item
expanded disability status scale (edss) < 6
boolean
C0451246 (UMLS CUI [1])
Therapy naive | Rebif Formulation New
Item
naïve subjects or subjects treated with rebif® new formulation for no more than 6 weeks prior to enrollment
boolean
C0919936 (UMLS CUI [1])
C0752980 (UMLS CUI [2,1])
C0524527 (UMLS CUI [2,2])
C0205314 (UMLS CUI [2,3])
Informed Consent
Item
subjects who have given written informed consent to participate in the study
boolean
C0021430 (UMLS CUI [1])
Multiple Sclerosis, Primary Progressive | Multiple Sclerosis, Secondary Progressive
Item
primary progressive or secondary progressive ms
boolean
C0751964 (UMLS CUI [1])
C0751965 (UMLS CUI [2])
Interferon beta-1a | Rebif | Interferon beta-1b | glatiramer acetate | Biological Response Modifiers | Immunosuppressive Agents | Therapeutic procedure Multiple Sclerosis | Exception Rebif Formulation New
Item
subjects previously administered ifn beta-1a (including rebif®) or ifn beta-1b or glatiramer acetate or any other immunomodulatory or immunosuppressive agents or any other ms therapy in the past with the exception of rebif® new formulation for no more than 6 weeks prior to enrollment
boolean
C0254119 (UMLS CUI [1])
C0752980 (UMLS CUI [2])
C0244713 (UMLS CUI [3])
C0289884 (UMLS CUI [4])
C0005525 (UMLS CUI [5])
C0021081 (UMLS CUI [6])
C0087111 (UMLS CUI [7,1])
C0026769 (UMLS CUI [7,2])
C1705847 (UMLS CUI [8,1])
C0752980 (UMLS CUI [8,2])
C0524527 (UMLS CUI [8,3])
C0205314 (UMLS CUI [8,4])
Adrenal Cortex Hormones Oral | CORTICOSTEROIDS FOR SYSTEMIC USE | ACTH
Item
subjects receiving oral or systemic corticosteroids or adrenocorticotrophic hormone within 30 days of visit 1 (prior to enrolment)
boolean
C0001617 (UMLS CUI [1,1])
C1527415 (UMLS CUI [1,2])
C3653708 (UMLS CUI [2])
C0001655 (UMLS CUI [3])
Chronic pain syndrome
Item
history of any chronic pain syndrome
boolean
C1298685 (UMLS CUI [1])
Hypersensitivity Interferon | Hypersensitivity Interferon Excipient
Item
known allergy to ifn or its excipients
boolean
C0020517 (UMLS CUI [1,1])
C3652465 (UMLS CUI [1,2])
C0020517 (UMLS CUI [2,1])
C3652465 (UMLS CUI [2,2])
C0015237 (UMLS CUI [2,3])
Heart Disease | Cardiac Arrhythmia Uncontrolled | Angina Pectoris Uncontrolled | Cardiomyopathy | Congestive heart failure Uncontrolled
Item
serious or acute heart disease such as uncontrolled cardiac dysrhythmias, uncontrolled angina pectoris, cardiomyopathy, or uncontrolled congestive heart failure
boolean
C0018799 (UMLS CUI [1])
C0003811 (UMLS CUI [2,1])
C0205318 (UMLS CUI [2,2])
C0002962 (UMLS CUI [3,1])
C0205318 (UMLS CUI [3,2])
C0878544 (UMLS CUI [4])
C0018802 (UMLS CUI [5,1])
C0205318 (UMLS CUI [5,2])
Liver function Inadequate | Alanine aminotransferase increased | Alkaline phosphatase raised | Elevated total bilirubin
Item
inadequate liver function, defined by a alanine aminotransferase (alt) > 3 x upper limit of normal (uln), or alkaline phosphatase > 2 x uln, or total bilirubin > 2 x uln if associated with any elevation of alt or alkaline phosphatase
boolean
C0232741 (UMLS CUI [1,1])
C0205412 (UMLS CUI [1,2])
C0151905 (UMLS CUI [2])
C0151849 (UMLS CUI [3])
C0741494 (UMLS CUI [4])
Few mature neutrophils in the bone marrow | White blood cell count decreased
Item
inadequate bone marrow reserve, defined as a white blood cell count less than 0.5 x lower limit of normal
boolean
C2748959 (UMLS CUI [1])
C0750394 (UMLS CUI [2])
Substance Use Disorders
Item
current or past (within the last 2 years) history of alcohol or drug abuse
boolean
C0038586 (UMLS CUI [1])
Medical contraindication Interferon beta-1a
Item
contra-indications to ifn beta-1a
boolean
C1301624 (UMLS CUI [1,1])
C0254119 (UMLS CUI [1,2])