Multiple Sclerosis, Relapsing-Remitting
Item
relapsing-remitting ms according to the revised mcdonald-criteria (2005)
boolean
C0751967 (UMLS CUI [1])
EDSS
Item
edss ≤ 4.0
boolean
C0451246 (UMLS CUI [1])
Interferon beta-1b Stable
Item
stable treatment with interferon-β1b for at least 6 months
boolean
C0244713 (UMLS CUI [1,1])
C0205360 (UMLS CUI [1,2])
Contraceptive methods | Other Coding
Item
sufficient birth control (pearl-index <1)
boolean
C0700589 (UMLS CUI [1])
C3846158 (UMLS CUI [2])
Multiple Sclerosis Except Relapsing-Remitting Multiple Sclerosis
Item
any other ms-course than rrms
boolean
C0026769 (UMLS CUI [1,1])
C0332300 (UMLS CUI [1,2])
C0751967 (UMLS CUI [1,3])
Gastrointestinal Diseases
Item
clinically relevant gastrointestinal disease
boolean
C0017178 (UMLS CUI [1])
Lung disease | Heart Disease | Communicable Disease | CNS disorder
Item
clinically relevant pulmonary, cardiological, infectious or cns-disease
boolean
C0024115 (UMLS CUI [1])
C0018799 (UMLS CUI [2])
C0009450 (UMLS CUI [3])
C0007682 (UMLS CUI [4])
Liver disease | Bile Duct Disease | Transaminases abnormal | Gamma-GT abnormal | Bilirubin abnormal
Item
clinically relevant disease of liver or bile system, pathological value for transaminases, gamma-gt or bilirubin.
boolean
C0023895 (UMLS CUI [1])
C0005395 (UMLS CUI [2])
C1328397 (UMLS CUI [3])
C0541979 (UMLS CUI [4])
C1142335 (UMLS CUI [5])
Hepatitis | Exception Hepatitis A Uncomplicated In complete remission
Item
hepatitis (except uncomplicated hepatitis a with complete remission
boolean
C0019158 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C0019159 (UMLS CUI [2,2])
C0443334 (UMLS CUI [2,3])
C0677874 (UMLS CUI [2,4])
Renal dysfunction | Creatinine measurement, serum | Bone Marrow Dysfunction | Hemoglobin measurement | White Blood Cell Count procedure | Platelet Count measurement
Item
clinically relevant dysfunction of kidneys (creatinine >180 µmol/l) or bone marrow (hb < 8.5 g/dl, wbc < 2.5/nl thrombocytes < 125/nl)
boolean
C3279454 (UMLS CUI [1])
C0201976 (UMLS CUI [2])
C0005953 (UMLS CUI [3,1])
C3887504 (UMLS CUI [3,2])
C0518015 (UMLS CUI [4])
C0023508 (UMLS CUI [5])
C0032181 (UMLS CUI [6])
Myasthenia Gravis
Item
myasthenia gravis
boolean
C0026896 (UMLS CUI [1])
Oral anticoagulants | Phenprocoumon
Item
oral anticoagulation (phenprocoumon)
boolean
C0354604 (UMLS CUI [1])
C0031444 (UMLS CUI [2])
Carbamazepine | Paracetamol
Item
treatment with carbamazepine or paracetamol
boolean
C0006949 (UMLS CUI [1])
C0000970 (UMLS CUI [2])
Substance Use Disorders
Item
drug or alcohol abuse
boolean
C0038586 (UMLS CUI [1])
Pregnancy | Breast Feeding
Item
pregnancy or lactation period
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Lymphatic Radiation Therapy Complete | Monoclonal Antibody Therapy | Anti-CD4 Monoclonal Antibody | Campath 1H | natalizumab | Mitoxantrone | Cyclophosphamide | Cyclosporine | Azathioprine
Item
treatment at any time before or during study with complete lymphoradiation, monoclonal antibodies (e.g. anti-cd4, campath 1h, natalizumab), mitoxantrone, cyclophosphamide, cyclosporin, azathioprine
boolean
C0086572 (UMLS CUI [1,1])
C0205197 (UMLS CUI [1,2])
C0279694 (UMLS CUI [2])
C3831519 (UMLS CUI [3])
C1178562 (UMLS CUI [4])
C1172734 (UMLS CUI [5])
C0026259 (UMLS CUI [6])
C0010583 (UMLS CUI [7])
C0010592 (UMLS CUI [8])
C0004482 (UMLS CUI [9])
Biological Response Modifiers | Exception Interferon beta-1b | Exception Methylprednisolone Intravenous
Item
treatment within 6 months before randomization with any other immunomodulatory substance than interferon-β1b or intravenous methylprednisolone
boolean
C0005525 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C0244713 (UMLS CUI [2,2])
C1705847 (UMLS CUI [3,1])
C0025815 (UMLS CUI [3,2])
C1522726 (UMLS CUI [3,3])