Leukemia, Myelocytic, Acute | MYELODYSPLASTIC SYNDROME High risk | Allogeneic Stem Cell Transplantation second | Donor Same Recurrent disease | Donor Different Recurrent disease | Hematologic Neoplasms | Acute lymphocytic leukemia
Item
patients with the following diseases: acute myeloid leukemia (aml) and high risk myelodysplastic syndrome (mds) undergoing second allogeneic (allo)-stem cell transplant (sct) using the same donor or different donor for disease relapse; patients with other hematologic malignancies, including acute lymphoblastic leukemia (all), will be at the discretion of the investigators
boolean
C0023467 (UMLS CUI [1])
C3463824 (UMLS CUI [2,1])
C4319571 (UMLS CUI [2,2])
C2242529 (UMLS CUI [3,1])
C0205436 (UMLS CUI [3,2])
C0040288 (UMLS CUI [4,1])
C0445247 (UMLS CUI [4,2])
C0277556 (UMLS CUI [4,3])
C0040288 (UMLS CUI [5,1])
C1705242 (UMLS CUI [5,2])
C0277556 (UMLS CUI [5,3])
C0376545 (UMLS CUI [6])
C0023449 (UMLS CUI [7])
Karnofsky Performance Status
Item
karnofsky performance status of 70 or above
boolean
C0206065 (UMLS CUI [1])
Life Expectancy | Limitation Severe Absent
Item
life expectancy is not severely limited by concomitant illness
boolean
C0023671 (UMLS CUI [1])
C0449295 (UMLS CUI [2,1])
C0205082 (UMLS CUI [2,2])
C0332197 (UMLS CUI [2,3])
Cardiac function | Pulmonary function | Left ventricular ejection fraction decreased | Percent Predicted DLCO | Evaluation Before Enrollment
Item
adequate cardiac and pulmonary function; patients with decreased left ventricular ejection fraction (lvef) =< 40% or diffusion capacity of carbon monoxide (dlco) =< 50% of predicted will be evaluated by cardiology or pulmonary prior to enrollment on this protocol
boolean
C0232164 (UMLS CUI [1])
C0231921 (UMLS CUI [2])
C1096403 (UMLS CUI [3])
C4054207 (UMLS CUI [4])
C1261322 (UMLS CUI [5,1])
C0332152 (UMLS CUI [5,2])
C1516879 (UMLS CUI [5,3])
Creatinine measurement, serum | Creatinine clearance measurement
Item
serum creatinine =<1.5 mg/dl or creatinine clearance > 50 ml/min; some patients with minor deviations may be accepted on protocol after discussion with the principal investigator (pi)
boolean
C0201976 (UMLS CUI [1])
C0373595 (UMLS CUI [2])
Serum total bilirubin measurement
Item
serum bilirubin =< 2.0 mg/dl; some patients with minor deviations may be accepted on protocol after discussion with the pi
boolean
C1278039 (UMLS CUI [1])
Aspartate aminotransferase measurement
Item
serum glutamic oxaloacetic transaminase (sgpt) < 5 x upper limit of normal; some patients with minor deviations may be accepted on protocol after discussion with the pi
boolean
C0201899 (UMLS CUI [1])
Chronic Hepatitis Absent | Chronic Liver Cirrhosis Absent
Item
no evidence of chronic active hepatitis or cirrhosis
boolean
C0019189 (UMLS CUI [1,1])
C0332197 (UMLS CUI [1,2])
C0023890 (UMLS CUI [2,1])
C0205191 (UMLS CUI [2,2])
C0332197 (UMLS CUI [2,3])
HIV negative
Item
human immunodeficiency virus (hiv)-negative
boolean
C0481430 (UMLS CUI [1])
Pregnancy Absent
Item
patient is not pregnant
boolean
C0032961 (UMLS CUI [1,1])
C0332197 (UMLS CUI [1,2])
Informed Consent | Informed Consent Guardian
Item
patient or guardian able to sign informed consent
boolean
C0021430 (UMLS CUI [1])
C0021430 (UMLS CUI [2,1])
C1274041 (UMLS CUI [2,2])
Donor | Donor Matched Same | Allogeneic Stem Cell Transplantation First | Allogeneic Stem Cell Transplantation second | Donors multiple | Donor Matched Alternative | Matched Related Donor | Matched Unrelated Donor
Item
donor: since these patients already had first allo-sct; in the majority time, the same matched donor has been used for second allo-sct; if the patients have multiple donors, alternative matched (8/8 or 10/10) donor could be used for the second allo-sct; the donor could be matched related donors or matched unrelated donors from registry
boolean
C0040288 (UMLS CUI [1])
C0040288 (UMLS CUI [2,1])
C0150103 (UMLS CUI [2,2])
C0445247 (UMLS CUI [2,3])
C2242529 (UMLS CUI [3,1])
C0205435 (UMLS CUI [3,2])
C2242529 (UMLS CUI [4,1])
C0205436 (UMLS CUI [4,2])
C0040288 (UMLS CUI [5,1])
C0439064 (UMLS CUI [5,2])
C0040288 (UMLS CUI [6,1])
C0150103 (UMLS CUI [6,2])
C1523987 (UMLS CUI [6,3])
C4330663 (UMLS CUI [7])
C4318937 (UMLS CUI [8])
Donor | Matched Unrelated Donor Quantity | Selection further
Item
donor: if more than one potential volunteer unrelated donor is considered suitable, further selection of the most suitable donor will be prioritized as follows or will follow our institutional guideline from our stem cell transplant standard operating procedure (sop):
boolean
C0040288 (UMLS CUI [1])
C4318937 (UMLS CUI [2,1])
C1265611 (UMLS CUI [2,2])
C1707391 (UMLS CUI [3,1])
C1524062 (UMLS CUI [3,2])
Age Donor
Item
age of donor (18-24 > 25-34 > 35-44 > 45+)
boolean
C0001779 (UMLS CUI [1,1])
C0040288 (UMLS CUI [1,2])
Gender Donor | Gender Nulliparous | Gender Parous cervix | Gender Multiparity
Item
sex of donor (male > female, nulliparous female > parous, multiparous female)
boolean
C0079399 (UMLS CUI [1,1])
C0040288 (UMLS CUI [1,2])
C0079399 (UMLS CUI [2,1])
C0425979 (UMLS CUI [2,2])
C0079399 (UMLS CUI [3,1])
C2045006 (UMLS CUI [3,2])
C0079399 (UMLS CUI [4,1])
C0026751 (UMLS CUI [4,2])
Cytomegalovirus status | Recipient Cytomegalovirus Seronegative | Recipient Cytomegalovirus Seropositive
Item
cytomegalovirus (cmv) status, if recipient is cmv seronegative (cmv- > cmv+
boolean
C0582172 (UMLS CUI [1])
C1709854 (UMLS CUI [2,1])
C0010825 (UMLS CUI [2,2])
C0521144 (UMLS CUI [2,3])
C1709854 (UMLS CUI [3,1])
C0010825 (UMLS CUI [3,2])
C0521143 (UMLS CUI [3,3])