Follicular Lymphoma Ann Arbor lymphoma staging system | Follicular Lymphoma Grade
Item
1. newly diagnosed patients with stage i and ii follicular lymphoma, pathologically confirmed at mdacc to be grade 1 or 2.
boolean
C0024301 (UMLS CUI [1,1])
C0432516 (UMLS CUI [1,2])
C0024301 (UMLS CUI [2,1])
C0441800 (UMLS CUI [2,2])
Prophylactic treatment Lamivudine | Antibody test positive | Communicable Disease Absent
Item
2. prophylactic use of lamivudine in patients that have antibody +, but no active infection will be up to the treating physician.
boolean
C0199176 (UMLS CUI [1,1])
C0209738 (UMLS CUI [1,2])
C0741132 (UMLS CUI [2])
C0009450 (UMLS CUI [3,1])
C0332197 (UMLS CUI [3,2])
Age
Item
3. >/= 18 at the time of signing the informed consent form
boolean
C0001779 (UMLS CUI [1])
Bone Marrow Mature Neutrophils Present | Absolute neutrophil count | Platelet Count measurement | Hemoglobin measurement
Item
4. patients are required to have adequate bone marrow reserve as indicated: * absolute neutrophil count (anc) /=> 1000/mm^3 *platelets >/= 80,000/mm^3, *hemoglobin >/= 8g/dl. these values must be obtained within two weeks before protocol entry.
boolean
C0005953 (UMLS CUI [1,1])
C1708947 (UMLS CUI [1,2])
C0948762 (UMLS CUI [2])
C0032181 (UMLS CUI [3])
C0518015 (UMLS CUI [4])
Liver function | Serum total bilirubin measurement | Alanine aminotransferase measurement | Aspartate aminotransferase measurement
Item
5. patients must have adequate liver function as indicated by: *bilirubin </= 1.5 times the upper limit of normal (uln), *alanine transaminase (alt) </= 2 times the (uln) or aspartate transaminase (ast) </= 2 times the uln, these values must be obtained within two weeks before protocol entry. performance status >/= 2
boolean
C0232741 (UMLS CUI [1])
C1278039 (UMLS CUI [2])
C0201836 (UMLS CUI [3])
C0201899 (UMLS CUI [4])
Renal function | Creatinine measurement, serum
Item
6. patients are required to have adequate renal function as indicated by a serum creatinine </= 2.5 mg/dl. this value must be obtained within two weeks before protocol entry.
boolean
C0232804 (UMLS CUI [1])
C0201976 (UMLS CUI [2])
Allergic Reaction Absent Monoclonal Antibodies
Item
7. no prior known allergic reaction to monoclonal antibodies.
boolean
C1527304 (UMLS CUI [1,1])
C0332197 (UMLS CUI [1,2])
C0003250 (UMLS CUI [1,3])
Gender Barrier Contraception | Gender Sexual Abstinence Coitus
Item
8. male patients must agree to use a barrier method of contraception or agree to abstain from heterosexual activity for the duration of the study.
boolean
C0079399 (UMLS CUI [1,1])
C0004764 (UMLS CUI [1,2])
C0079399 (UMLS CUI [2,1])
C0036899 (UMLS CUI [2,2])
C0009253 (UMLS CUI [2,3])
Gender Barrier Contraception Quantity | Gender Sexual Abstinence Coitus | Postmenopausal state | Female Sterilization
Item
9. female patients must be willing to use two adequate barrier methods of contraception to prevent pregnancy or agree to abstain from heterosexual activity throughout the study or be post menopausal (free from menses > two years or surgically sterilized).
boolean
C0079399 (UMLS CUI [1,1])
C0004764 (UMLS CUI [1,2])
C1265611 (UMLS CUI [1,3])
C0079399 (UMLS CUI [2,1])
C0036899 (UMLS CUI [2,2])
C0009253 (UMLS CUI [2,3])
C0232970 (UMLS CUI [3])
C0015787 (UMLS CUI [4])
Childbearing Potential Serum pregnancy test (B-HCG) Negative
Item
10. female patients of childbearing potential must have a negative serum pregnancy test (b hcg) within 72 hours of receiving the first dose of rituximab
boolean
C3831118 (UMLS CUI [1,1])
C0430060 (UMLS CUI [1,2])
C1513916 (UMLS CUI [1,3])
Informed Consent
Item
11. patients must have the ability able to give informed consent.
boolean
C0021430 (UMLS CUI [1])
Hepatitis B | Hepatitis C
Item
1. patients with active hepatitis b and/or hepatitis c infection.
boolean
C0019163 (UMLS CUI [1])
C0019196 (UMLS CUI [2])
HIV Infection
Item
2. patients with known hiv infection
boolean
C0019693 (UMLS CUI [1])
Communicable Diseases Requirement Anti-infective therapy
Item
3. patients with active infections requiring specific anti-infective therapy are not eligible until all signs of infections are resolved.
boolean
C0009450 (UMLS CUI [1,1])
C1514873 (UMLS CUI [1,2])
C1141958 (UMLS CUI [1,3])
Prior Radiation Therapy Site Disease Current
Item
4. patients who had previous radiation dose to the site of the current primary disease, which would lead to violation of known radiation tolerance limit of that particular site if treated again.
boolean
C0279134 (UMLS CUI [1,1])
C1515974 (UMLS CUI [1,2])
C0012634 (UMLS CUI [1,3])
C0521116 (UMLS CUI [1,4])
Cardiovascular Disease Pre-existing Treatment required for | Congestive heart failure New York Heart Association Classification | Cardiac Arrhythmia Uncontrolled | Angina, Unstable | Myocardial Infarction
Item
5. patients with pre-existing cardiovascular disease requiring ongoing treatment. this includes: a. congestive heart failure iii/iv as defined by new york heart association (nyha) b. uncontrolled cardiac arrhythmia, c. unstable angina pectoris, d. recent mi (within 6 months).
boolean
C0007222 (UMLS CUI [1,1])
C2347662 (UMLS CUI [1,2])
C0332121 (UMLS CUI [1,3])
C0018802 (UMLS CUI [2,1])
C1275491 (UMLS CUI [2,2])
C0003811 (UMLS CUI [3,1])
C0205318 (UMLS CUI [3,2])
C0002965 (UMLS CUI [4])
C0027051 (UMLS CUI [5])
Pregnancy | Breast Feeding
Item
6. patients who are pregnant or breast-feeding.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Pharmaceutical Preparations Alternative
Item
7. patient with concurrent use of complementary or alternative medicines.
boolean
C0013227 (UMLS CUI [1,1])
C1523987 (UMLS CUI [1,2])
Mental disorders Limiting Medication Compliance | Social situation Limiting Medication Compliance | Mental disorders Limiting Protocol Compliance | Social situation Limiting Protocol Compliance
Item
8. patients with psychiatric illness and/or social situations that would limit compliance with the study medication and requirements.
boolean
C0004936 (UMLS CUI [1,1])
C0439801 (UMLS CUI [1,2])
C3489773 (UMLS CUI [1,3])
C0748872 (UMLS CUI [2,1])
C0439801 (UMLS CUI [2,2])
C3489773 (UMLS CUI [2,3])
C0004936 (UMLS CUI [3,1])
C0439801 (UMLS CUI [3,2])
C0525058 (UMLS CUI [3,3])
C0748872 (UMLS CUI [4,1])
C0439801 (UMLS CUI [4,2])
C0525058 (UMLS CUI [4,3])