Adult | Age
Item
adult patients, >/= 18 and </= 80 years of age
boolean
C0001675 (UMLS CUI [1])
C0001779 (UMLS CUI [2])
Diffuse Large B-Cell Lymphoma CD20 positive Untreated | Follicular Lymphoma CD20 positive WHO tumor classification
Item
histologically confirmed, previously untreated cd20+ diffuse large b-cell lymphoma (dlbcl) or cd20+ follicular non-hodgkin's lymphoma (nhl) grade 1, 2, or 3a, according to who classification
boolean
C0079744 (UMLS CUI [1,1])
C3888518 (UMLS CUI [1,2])
C0332155 (UMLS CUI [1,3])
C0024301 (UMLS CUI [2,1])
C3888518 (UMLS CUI [2,2])
C1301142 (UMLS CUI [2,3])
International Prognostic Index | Bulky Disease | Lesion Size Quantity | Follicular Lymphoma International Prognostic Index
Item
an international prognostic index (ipi) score of 1-4 or ipi score of 0 with bulky disease, defined as one lesion >/= 7.5 cm, or follicular lymphoma international prognostic index (flipi; low, intermediate or high risk)
boolean
C1512894 (UMLS CUI [1])
C1511341 (UMLS CUI [2])
C0221198 (UMLS CUI [3,1])
C0456389 (UMLS CUI [3,2])
C1265611 (UMLS CUI [3,3])
C4040298 (UMLS CUI [4])
Measurable lesion 2-Dimensional Quantity | Lesion size, largest dimension CT
Item
at least one bi-dimensionally measurable lesion defined as >/=1.5 cm in its largest dimension on ct scan
boolean
C1513041 (UMLS CUI [1,1])
C1705052 (UMLS CUI [1,2])
C1265611 (UMLS CUI [1,3])
C1275593 (UMLS CUI [2,1])
C0040405 (UMLS CUI [2,2])
ECOG performance status
Item
eastern cooperative oncology group (ecog) performance status </= 3
boolean
C1520224 (UMLS CUI [1])
Transformation Lymphoma | Follicular Lymphoma Ann Arbor lymphoma staging system
Item
transformed lymphoma or follicular lymphoma iiib
boolean
C0040682 (UMLS CUI [1,1])
C0024299 (UMLS CUI [1,2])
C0024301 (UMLS CUI [2,1])
C0432516 (UMLS CUI [2,2])
Primary central nervous system lymphoma | Transformation Burkitt Lymphoma | Mediastinal (Thymic) Large B-Cell Lymphoma | Primary Effusion Lymphoma | Primary cutaneous diffuse large cell B-cell lymphoma | Large B-cell diffuse lymphoma of testis
Item
primary central nervous system (cns) lymphoma, histologic evidence of transformation to burkitt lymphoma, primary mediastinal dlbcl, primary effusion lymphoma, primary cutaneous dlbcl, or primary dlbcl of the testis
boolean
C0280803 (UMLS CUI [1])
C0040682 (UMLS CUI [2,1])
C0006413 (UMLS CUI [2,2])
C1292754 (UMLS CUI [3])
C1292753 (UMLS CUI [4])
C1275325 (UMLS CUI [5])
C2057634 (UMLS CUI [6])
Cancer Other Affecting Protocol Compliance | Cancer Other Affecting Interpretation Research results | Exception Cancer Remission Duration | Exception Curative treatment Basal cell carcinoma | Exception Curative treatment Squamous cell carcinoma of skin | Exception Curative treatment Cutaneous Melanoma | Exception Curative treatment Carcinoma in situ of uterine cervix
Item
history of other malignancy that could affect compliance with the protocol or interpretation of the results; this includes a malignancy that has been treated but not with curative intent, unless the malignancy has been in remission for >/= 5 years prior to enrolment; patients with a history of curatively treated basal or squamous cell carcinoma or melanoma of the skin or in situ carcinoma of the cervix are eligible
boolean
C1707251 (UMLS CUI [1,1])
C0392760 (UMLS CUI [1,2])
C0525058 (UMLS CUI [1,3])
C1707251 (UMLS CUI [2,1])
C0392760 (UMLS CUI [2,2])
C0459471 (UMLS CUI [2,3])
C0683954 (UMLS CUI [2,4])
C1705847 (UMLS CUI [3,1])
C0687702 (UMLS CUI [3,2])
C0449238 (UMLS CUI [3,3])
C1705847 (UMLS CUI [4,1])
C1273390 (UMLS CUI [4,2])
C0007117 (UMLS CUI [4,3])
C1705847 (UMLS CUI [5,1])
C1273390 (UMLS CUI [5,2])
C0553723 (UMLS CUI [5,3])
C1705847 (UMLS CUI [6,1])
C1273390 (UMLS CUI [6,2])
C0151779 (UMLS CUI [6,3])
C1705847 (UMLS CUI [7,1])
C1273390 (UMLS CUI [7,2])
C0851140 (UMLS CUI [7,3])
Prior Therapy Diffuse Large B-Cell Lymphoma | Prior Therapy Non-Hodgkin Lymphoma | Exception Biopsy of lymph node | Exception Therapeutic radiology procedure Local
Item
prior therapy for dlbcl or nhl, with the exception of nodal biopsy or local irradiation
boolean
C1514463 (UMLS CUI [1,1])
C0079744 (UMLS CUI [1,2])
C1514463 (UMLS CUI [2,1])
C0024305 (UMLS CUI [2,2])
C1705847 (UMLS CUI [3,1])
C0193842 (UMLS CUI [3,2])
C1705847 (UMLS CUI [4,1])
C1522449 (UMLS CUI [4,2])
C0205276 (UMLS CUI [4,3])
Cytotoxic agent | Exception Intrathecal Methotrexate Regimen Central Nervous System Prophylaxis | rituximab | Pharmaceutical Preparations Against CD20
Item
prior treatment with cytotoxic drugs (with the exclusion of intrathecal methotrexate for cns prophylaxis in dlbcl) or rituximab for another condition, or prior use of an anti-cd20 drug
boolean
C0304497 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C5204906 (UMLS CUI [2,2])
C1516386 (UMLS CUI [2,3])
C0393022 (UMLS CUI [3])
C0013227 (UMLS CUI [4,1])
C0521124 (UMLS CUI [4,2])
C0054946 (UMLS CUI [4,3])
Monoclonal Antibodies
Item
prior use of monoclonal antibody within 3 months prior to randomization
boolean
C0003250 (UMLS CUI [1])
Chemotherapy | Therapies, Investigational
Item
chemotherapy or other investigational therapy within 28 days prior to randomization
boolean
C0392920 (UMLS CUI [1])
C0949266 (UMLS CUI [2])
Adrenal Cortex Hormones | Prednisolone U/day | Equivalent
Item
ongoing corticosteroid use > 30 mg/day prednisolone or equivalent
boolean
C0001617 (UMLS CUI [1])
C0032950 (UMLS CUI [2,1])
C0456683 (UMLS CUI [2,2])
C0205163 (UMLS CUI [3])
Renal function Inadequate | Hematologic function Inadequate | Liver function Inadequate
Item
inadequate renal. hematologic or hepatic function
boolean
C0232804 (UMLS CUI [1,1])
C0205412 (UMLS CUI [1,2])
C0221130 (UMLS CUI [2,1])
C0205412 (UMLS CUI [2,2])
C0232741 (UMLS CUI [3,1])
C0205412 (UMLS CUI [3,2])
Communicable Disease | Communicable Disease Severe | Episode Major Communicable Disease
Item
active and/or severe infection or any major episode of infection within 4 weeks prior to randomization
boolean
C0009450 (UMLS CUI [1])
C0009450 (UMLS CUI [2,1])
C0205082 (UMLS CUI [2,2])
C0332189 (UMLS CUI [3,1])
C0205164 (UMLS CUI [3,2])
C0009450 (UMLS CUI [3,3])
Hepatitis B | Hepatitis C
Item
active hepatitis b virus or active hepatitis c virus infection
boolean
C0019163 (UMLS CUI [1])
C0019196 (UMLS CUI [2])
HIV Seropositivity
Item
history of human immunodeficiency (hiv) seropositive status
boolean
C0019699 (UMLS CUI [1])
Pregnancy test positive
Item
a positive pregnancy test in women of childbearing potential
boolean
C0240802 (UMLS CUI [1])
Life Expectancy
Item
life expectancy of less than 6 months
boolean
C0023671 (UMLS CUI [1])