Histologically confirmed papillary thyroid carcinoma, including its variants
Item
histologically confirmed papillary thyroid carcinoma, including its variants, such as tall cell ptc or poorly differentiated thyroid carcinoma, that is metastatic or unresectable and harbors a braf v600e mutation
boolean
C0238463 (UMLS CUI [1,1])
C0332257 (UMLS CUI [1,2])
C0205419 (UMLS CUI [1,3])
Evaluable disease | Measurable disease by CT or ultrasound (neck localization)
Item
evaluable disease, as defined by at least one lesion that can be accurately measured in at least one dimension on ct scan or ultrasound, if present in the neck
boolean
C1516986 (UMLS CUI [1])
C1513041 (UMLS CUI [2,1])
C1265611 (UMLS CUI [2,2])
C0040405 (UMLS CUI [2,3])
C1513041 (UMLS CUI [3,1])
C1265611 (UMLS CUI [3,2])
C0041618 (UMLS CUI [3,3])
C0027530 (UMLS CUI [3,4])
C0475264 (UMLS CUI [3,5])
Radioiodine refractory disease
Item
radioiodine-refractory disease
boolean
C0303029 (UMLS CUI [1,1])
C0205269 (UMLS CUI [1,2])
Life expectancy
Item
life expectancy > 6 months
boolean
C0023671 (UMLS CUI [1])
Able to swallow and retain oral medication
Item
able to swallow and retain oral medication
boolean
C0175795 (UMLS CUI [1,1])
C2712086 (UMLS CUI [1,2])
C0175795 (UMLS CUI [2,1])
C0333118 (UMLS CUI [2,2])
C0085732 (UMLS CUI [2,3])
Normal organ function | Normal bone marrow function
Item
normal organ and marrow function
boolean
C0678852 (UMLS CUI [1,1])
C0205307 (UMLS CUI [1,2])
C0005953 (UMLS CUI [2,1])
C0031843 (UMLS CUI [2,2])
C0205307 (UMLS CUI [2,3])
Pregnancy | Breastfeeding
Item
pregnant or breastfeeding
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Prior therapy with a specific BRAF or MEK inhibitor
Item
previous treatment with a specific braf or mek inhibitor
boolean
C1514463 (UMLS CUI [1,1])
C3838813 (UMLS CUI [1,2])
C1514463 (UMLS CUI [2,1])
C1513344 (UMLS CUI [2,2])
Other therapy with experimental drug
Item
receiving any other study agents
boolean
C0418967 (UMLS CUI [1,1])
C0304229 (UMLS CUI [1,2])
Brain metastases
Item
known brain metastases
boolean
C0220650 (UMLS CUI [1])
Hypersensitivity to compounds of similar chemical or biologic composition to gsk2118436, bovine tsh, mannitol or iodine
Item
history of allergic reactions attributed to compounds of similar chemical or biologic composition to gsk2118436, bovine tsh, mannitol or iodine
boolean
C2826139 (UMLS CUI [1,1])
C1706082 (UMLS CUI [1,2])
C2348205 (UMLS CUI [1,3])
C0020517 (UMLS CUI [1,4])
C0040160 (UMLS CUI [2,1])
C3667982 (UMLS CUI [2,2])
C1706082 (UMLS CUI [2,3])
C2348205 (UMLS CUI [2,4])
C0020517 (UMLS CUI [2,5])
C0024730 (UMLS CUI [3,1])
C1706082 (UMLS CUI [3,2])
C2348205 (UMLS CUI [3,3])
C0020517 (UMLS CUI [3,4])
C0021968 (UMLS CUI [4,1])
C1706082 (UMLS CUI [4,2])
C2348205 (UMLS CUI [4,3])
C0020517 (UMLS CUI [4,4])
Active gastrointestinal disease | Condition interfering with the absorption of drugs
Item
active gastrointestinal disease or other condition that will interfere significantly with the absorption of drugs
boolean
C0017178 (UMLS CUI [1,1])
C2707252 (UMLS CUI [1,2])
C0348080 (UMLS CUI [2,1])
C0521102 (UMLS CUI [2,2])
C0237442 (UMLS CUI [2,3])
C0013227 (UMLS CUI [2,4])
C2826293 (UMLS CUI [2,5])
Glucose-6-phosphate dehyrogenase deficiency
Item
history of known glucose-6-phosphate dehyrogenase (g6pd) deficiency
boolean
C2939465 (UMLS CUI [1,1])
C0262926 (UMLS CUI [1,2])
Corrected qt interval | History of acute coronary syndromes | Coronary angioplasty recent | Coronary stenting recent | Heart failure, NYHA classification | Abnormal cardiac valve morphology | History of known cardiac arrhythmias
Item
corrected qt interval >/= 480 msecs; history of acute coronary syndromes (including unstable angina), coronary angioplasty, or stenting within the past 24 weeks; class ii, iii, or iv heart failure, abnormal cardiac valve morphology; or history of known cardiac arrhythmias
boolean
C0855331 (UMLS CUI [1])
C0948089 (UMLS CUI [2,1])
C0262926 (UMLS CUI [2,2])
C0190211 (UMLS CUI [3,1])
C0332185 (UMLS CUI [3,2])
C0948884 (UMLS CUI [4,1])
C0332185 (UMLS CUI [4,2])
C0018801 (UMLS CUI [5,1])
C1275491 (UMLS CUI [5,2])
C0018826 (UMLS CUI [6,1])
C0332437 (UMLS CUI [6,2])
C0205161 (UMLS CUI [6,3])
C0003811 (UMLS CUI [7,1])
C0262926 (UMLS CUI [7,2])
Herbal remedies
Item
taking herbal remedies
boolean
C2240391 (UMLS CUI [1])
Significant symptoms of thyroid cancer | Rapidly progressive iodine-refractory ptc in need of other systemic therapy
Item
subjects with significant symptoms from their thyroid cancer, or have a large burden of rapidly progressive iodine-refractory ptc who are in need of other systemic therapy, as judged by their treating physician
boolean
C0238463 (UMLS CUI [1,1])
C1457887 (UMLS CUI [1,2])
C2826293 (UMLS CUI [1,3])
C0238463 (UMLS CUI [2,1])
C1838681 (UMLS CUI [2,2])
C0303029 (UMLS CUI [2,3])
C0205269 (UMLS CUI [2,4])
C0920425 (UMLS CUI [2,5])
C0205373 (UMLS CUI [2,6])
C0027552 (UMLS CUI [2,7])
Uncontrolled comorbidity
Item
uncontrolled current illness including, but not limited to: ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, uncontrolled hypertension or psychiatric illness/social situations that would limit compliance with study requirements
boolean
C0009488 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])
History of a different malignancy unless disease-free for at least 5 years and deemed to be at low risk for recurrence
Item
history of a different malignancy unless disease-free for at least 5 years and deemed to be at low risk for recurrence
boolean
C0006826 (UMLS CUI [1,1])
C0205394 (UMLS CUI [1,2])
C0262926 (UMLS CUI [1,3])
C1705847 (UMLS CUI [2,1])
C0012634 (UMLS CUI [2,2])
C0332296 (UMLS CUI [2,3])
C0449238 (UMLS CUI [2,4])
C0034897 (UMLS CUI [2,5])
C3538919 (UMLS CUI [2,6])
HIV seropositivity on combination antiretroviral therapy
Item
hiv-positive on combination antiretroviral therapy
boolean
C0019699 (UMLS CUI [1,1])
C1963724 (UMLS CUI [1,2])
C0205195 (UMLS CUI [1,3])