Age
Item
1. patients age >/=18 to </= 65 years.
boolean
C0001779 (UMLS CUI [1])
AML in remission | AML in relapse | Primary induction failure in AML | MDS (IPPS score) having failed to respond or recurred after chemotherapy | AML arising from MDS | CML which has failed to respond to imatinib or other tyrosine kinase inhibitor, blasts in the blood or bone marrow
Item
2. diagnosis of aml in first or greater remission, first or subsequent relapse, or primary induction failure; mds with intermediate or high risk international prognostic scoring system (ipss) score having failed to respond or recurred after chemotherapy; in remission or having active disease after treatment; aml arising from mds; or cml which has failed to respond to imatinib or other tyrosine kinase inhibitor and has had >5% blasts in the blood or bone marrow. patients receiving second transplants after relapse are considered in the relapse group.
boolean
C0023467 (UMLS CUI [1,1])
C0544452 (UMLS CUI [1,2])
C0023467 (UMLS CUI [2,1])
C0277556 (UMLS CUI [2,2])
C0023467 (UMLS CUI [3,1])
C2347677 (UMLS CUI [3,2])
C3463824 (UMLS CUI [4,1])
C2827405 (UMLS CUI [4,2])
C0392920 (UMLS CUI [4,3])
C0231175 (UMLS CUI [4,4])
C3463824 (UMLS CUI [5,1])
C2827405 (UMLS CUI [5,2])
C0392920 (UMLS CUI [5,3])
C0034897 (UMLS CUI [5,4])
C0023467 (UMLS CUI [6,1])
C0678226 (UMLS CUI [6,2])
C3463824 (UMLS CUI [6,3])
C0023473 (UMLS CUI [7,1])
C0935989 (UMLS CUI [7,2])
C0162643 (UMLS CUI [7,3])
C0368761 (UMLS CUI [7,4])
C0005953 (UMLS CUI [7,5])
C0368761 (UMLS CUI [7,6])
C0229664 (UMLS CUI [7,7])
C0023473 (UMLS CUI [8,1])
C1268567 (UMLS CUI [8,2])
C0162643 (UMLS CUI [8,3])
C0368761 (UMLS CUI [8,4])
C0005953 (UMLS CUI [8,5])
C0368761 (UMLS CUI [8,6])
C0229664 (UMLS CUI [8,7])
White blood cell count
Item
3. white blood count (cbc) </= 20 * 10^9/l.
boolean
C0023508 (UMLS CUI [1])
Histocompatible, related or unrelated volunteer donor available, HLA antigens
Item
4. patients should have a histocompatible, related or unrelated volunteer donor available. a histocompatible donor is defined as hla matched related donor or an unrelated donor matched for hla- a, b, c, and dr antigens by high-resolution dna techniques.
boolean
C0470187 (UMLS CUI [1,1])
C4330663 (UMLS CUI [1,2])
C0019721 (UMLS CUI [1,3])
C0470187 (UMLS CUI [2,1])
C4318937 (UMLS CUI [2,2])
C0019721 (UMLS CUI [2,3])
Zubrod performance status | Karnofsky performance status
Item
5. zubrod performance status 0 or 1, or karnofsky performance status 90-100%.
boolean
C3714786 (UMLS CUI [1])
C0206065 (UMLS CUI [2])
Left ventricular ejection fraction | Absence of uncontrolled arrythmias | Absence of uncontrolled symptomatic cardiac disease
Item
6. left ventricular ejection fraction >/= 45 %. no uncontrolled arrhythmias or uncontrolled symptomatic cardiac disease.
boolean
C0428772 (UMLS CUI [1])
C0003811 (UMLS CUI [2,1])
C0205318 (UMLS CUI [2,2])
C0332197 (UMLS CUI [2,3])
C0018799 (UMLS CUI [3,1])
C0231220 (UMLS CUI [3,2])
C0205318 (UMLS CUI [3,3])
C0332197 (UMLS CUI [3,4])
Absence of symptomatic pulmonary disease | FEV1 | FVC | DLCO
Item
7. no symptomatic pulmonary disease. forced expiratory volume in 1 s (fev1), forced vital capacity (fvc) and diffusion capacity of carbon monoxide (dlco) >/= 50 % of expected, corrected for hemoglobin.
boolean
C0024115 (UMLS CUI [1,1])
C0231220 (UMLS CUI [1,2])
C0332197 (UMLS CUI [1,3])
C0849974 (UMLS CUI [2])
C3714541 (UMLS CUI [3])
C1516251 (UMLS CUI [4])
Serum creatinine measurement
Item
8. serum creatinine </=1.5 mg/dl.
boolean
C0201976 (UMLS CUI [1])
Serum glutamic pyruvic transaminase | Serum glutamic pyruvic transaminase related to the malignancy
Item
9. serum glutamic pyruvic transaminase (sgpt) </= 200 iu/ml unless related to the malignancy.
boolean
C0201836 (UMLS CUI [1])
C0201836 (UMLS CUI [2,1])
C0586721 (UMLS CUI [2,2])
C1705847 (UMLS CUI [2,3])
C0006826 (UMLS CUI [2,4])
C0678226 (UMLS CUI [2,5])
Total serum bilirubin | Total serum bilirubin due to Gilbert's syndrome | ALP
Item
10. total serum bilirubin </=1.5 mg/dl (unless gilbert's syndrome) and alkaline phosphatase </=2.5 times laboratory standard upper limit of normal (uln).
boolean
C0201913 (UMLS CUI [1])
C0201913 (UMLS CUI [2,1])
C1705847 (UMLS CUI [2,2])
C0678226 (UMLS CUI [2,3])
C0017551 (UMLS CUI [2,4])
C0201850 (UMLS CUI [3])
Informed consent signed by patient | Informed consent signed by patient's legal representative
Item
11. patient or patient's legal representative able to sign informed consent.
boolean
C0021430 (UMLS CUI [1])
C0021430 (UMLS CUI [2,1])
C0030701 (UMLS CUI [2,2])
History of HIV seropositivity
Item
1. history of hiv positive.
boolean
C0019699 (UMLS CUI [1,1])
C0262926 (UMLS CUI [1,2])
HCG test positive in a woman with childbearing potential
Item
2. positive beta human chorionic gonadotropin (hcg) test in a woman with child bearing potential defined as not post-menopausal for 12 months or no previous surgical sterilization.
boolean
C3831118 (UMLS CUI [1,1])
C0032976 (UMLS CUI [1,2])
C0428402 (UMLS CUI [1,3])
C1446409 (UMLS CUI [1,4])
Pleural effusion | Pericardial effusion | Ascites
Item
3. pleural/pericardial effusion or ascites estimated >/= 1 liter.
boolean
C0032227 (UMLS CUI [1])
C0031039 (UMLS CUI [2])
C0003962 (UMLS CUI [3])
Uncontrolled infection not responding to antimicrobial agents after 7 days of therapy
Item
4. uncontrolled infection, not responding to appropriate antimicrobial agents after seven days of therapy.
boolean
C0009450 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])
C0443071 (UMLS CUI [1,3])
C0205269 (UMLS CUI [1,4])
C1948053 (UMLS CUI [1,5])
History of acute hepatitis | Chronic active hepatitis | Cirrhosis
Item
5. history of acute hepatitis, chronic active hepatitis or cirrhosis.
boolean
C0262926 (UMLS CUI [1,1])
C0267797 (UMLS CUI [1,2])
C0262926 (UMLS CUI [2,1])
C0520463 (UMLS CUI [2,2])
C0262926 (UMLS CUI [3,1])
C0023890 (UMLS CUI [3,2])
Agina pectoris, NYHA classification
Item
6. patients with class 3 or 4 angina (new york heart association (nyha) criteria).
boolean
C0002962 (UMLS CUI [1,1])
C1275491 (UMLS CUI [1,2])