Multiple Myeloma
Item
documented history of multiple myeloma,
boolean
C0026764 (UMLS CUI [1])
Multiple Myeloma | Regimen Quantity failed
Item
failed at least two prior regimens for multiple myeloma,
boolean
C0026764 (UMLS CUI [1])
C0040808 (UMLS CUI [2,1])
C1265611 (UMLS CUI [2,2])
C0231175 (UMLS CUI [2,3])
Age
Item
18 years of age or older,
boolean
C0001779 (UMLS CUI [1])
Zubrod Performance Status
Item
ecog(zubrod)ps of 0 to 2,
boolean
C3714786 (UMLS CUI [1])
Screening Evaluation Eligibility Determination
Item
screening evaluation for determining eligibility prior to enrollment,
boolean
C1409616 (UMLS CUI [1,1])
C0220825 (UMLS CUI [1,2])
C0013893 (UMLS CUI [1,3])
Informed Consent
Item
signed informed consent form,
boolean
C0021430 (UMLS CUI [1])
Pharmacotherapy Against Multiple Myeloma | Adrenal Cortex Hormones Against Multiple Myeloma | Chemotherapy Against Multiple Myeloma
Item
concomitant therapy medications including corticosteroids or other chemotherapy that is or may be active against myeloma ,
boolean
C0013216 (UMLS CUI [1,1])
C0521124 (UMLS CUI [1,2])
C0026764 (UMLS CUI [1,3])
C0001617 (UMLS CUI [2,1])
C0521124 (UMLS CUI [2,2])
C0026764 (UMLS CUI [2,3])
C0392920 (UMLS CUI [3,1])
C0521124 (UMLS CUI [3,2])
C0026764 (UMLS CUI [3,3])
Renal Insufficiency | Creatinine measurement, serum
Item
renal insufficiency (serum creatinine levels of > 2mg/dl),
boolean
C1565489 (UMLS CUI [1])
C0201976 (UMLS CUI [2])
Mucosal bleeding
Item
mucosal bleeding,
boolean
C2748540 (UMLS CUI [1])
Condition At risk Study Subject Participation Status
Item
any condition which in the opinion of the investigator, places the patient at unacceptable risk if he/she were to participate in the study.
boolean
C0348080 (UMLS CUI [1,1])
C1444641 (UMLS CUI [1,2])
C2348568 (UMLS CUI [1,3])
Communicable Disease Relevant Clinical | Comorbidity Relevant Clinical
Item
clinically relevant active infection or co-morbid medical conditions.
boolean
C0009450 (UMLS CUI [1,1])
C2347946 (UMLS CUI [1,2])
C0205210 (UMLS CUI [1,3])
C0009488 (UMLS CUI [2,1])
C2347946 (UMLS CUI [2,2])
C0205210 (UMLS CUI [2,3])
Malignant Neoplasms | Basal cell carcinoma Treated | Squamous cell carcinoma of skin Treated | Carcinoma in situ of uterine cervix Treated
Item
prior malignancy(within the last 3 years) except for adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, or other cancer for which the patient is has been disease-free for at least 3 years.
boolean
C0006826 (UMLS CUI [1])
C0007117 (UMLS CUI [2,1])
C1522326 (UMLS CUI [2,2])
C0553723 (UMLS CUI [3,1])
C1522326 (UMLS CUI [3,2])
C0851140 (UMLS CUI [4,1])
C1522326 (UMLS CUI [4,2])
Non-secretory myeloma
Item
patients with non-secretory myeloma.
boolean
C0456845 (UMLS CUI [1])
antiprimod | CYP2D6 | Adrenergic beta-Antagonists | Antidepressive Agents | Antipsychotic Agents
Item
as atiprimod is a potent inhibitor or cyp2d6, patients taking drugs that are substrates of cyp2d6(e.g. beta blockers, antidepressants and antipsychotics) will be excluded.
boolean
C1579206 (UMLS CUI [1])
C0057223 (UMLS CUI [2])
C0001645 (UMLS CUI [3])
C0003289 (UMLS CUI [4])
C0040615 (UMLS CUI [5])