Elig.phs000297.v1.p1.2
Item
*CASE DEFINITION*: Subject has ≥ 4 meds simultaneous* med classes below mentioned on at least 2 occasions ≥ 1 month apart (does not have to be the same med classes in each of the 2 occasions); OR Subject has *two* outpatient (if possible) measurements of SBP > 140 or DBP > 90 at least one month after meeting medication criteria while still on 3 simultaneous med classes AND has 3 simultaneous* med classes below (and does not meet Case Type 1) mentioned on at least 2 occasions ≥ 1 month apart (does not have to be the same med classes in each of the 2 occasions).
boolean
C1512693 (UMLS CUI [1,1])
C0003364 (UMLS CUI [1,2])
C1265611 (UMLS CUI [1,3])
C1512693 (UMLS CUI [3,1])
C0003364 (UMLS CUI [3,2])
C3476109 (UMLS CUI [3,3])
Elig.phs000297.v1.p1.7
Item
From the above, subjects with any of the following codes appearing in the record at any time were excluded: <th>ICD9 codes</th><th>Description</th> 194.0 MALIGN NEOPL ADRENAL 227.0 BENIGN NEOPLASM ADRENAL 255.0, 255.1, 255.2, 255.3, 255.6, 255.8, 255.9 Disorders of adrenal glands (excludes adrenal insufficiencies - 255.4 and 255.5) 405.* SECONDARY HYPERTENSION 416.* Chronic pulmonary heart disease 581.* Nephrotic syndrome 582.* Chronic glumerulonephritis 745.* Bulbus cordis anomalies 747.1* COARCTATION OF AORTA
boolean
C0680251 (UMLS CUI [1,1])
Elig.phs000297.v1.p1.8
Item
From the cases above, all subjects with the following codes were excluded only if the resistant hypertension only exists within five years before or after one of the codes below. For example, this means that one could ignore medications mentioned during a 5-year time frame before or after the below codes. <th>ICD9 codes</th><th>Description</th> 242.* Thyrotoxicosis 246 Disorder of thyrocalcitonin secretion 246.8 DISORDERS OF THYROID NEC 246.9 DISORDER OF THYROID NOS 252.8 PARATHYROID DISORDER NEC 252.9 PARATHYROID DISORDER NOS 320.2 ORGANIC SLEEP APNEA 327.21 PRIMARY CENTRAL SLEEP APNEA 327.23 OBSTRUCTIVE SLEEP APNEA 327.27 CEN SLEEP APNEA IN COND CLASS 327.29 OTHER ORGANIC SLEEP APNEA 599.6* OBSTRUCTIVE UROPATHY
boolean
C0680251 (UMLS CUI [1,1])
Elig.phs000297.v1.p1.10
Item
From the cases above, exclude the subject if *GFR < 30 ml/min* before the time of meeting the CASE 1 or 2 definitions or within 6 months after meeting the medication definition. *GFR should be calculated using the Modification of Diet in Renal Disease (MDRD) formula:* eGFR = 186 x Serum Creatinine<sup>-1.154</sup> x Age<sup>-0.203</sup> x [1.210 *if Black*] x [0.742 *if Female*] *(source: http://en.wikipedia.org/wiki/Renal_function#Estimated_GFR_.28eGFR.29_using_Modification_of_Diet_in_Renal_Disease_.28MDRD.29_formula)*
boolean
C0680251 (UMLS CUI [1,1])
Elig.phs000297.v1.p1.12
Item
Exclude all patients with an Ejection Fraction (EF or LVEF) <35% within 1 year before or after meeting the CASE 1 definition.
boolean
C0680251 (UMLS CUI [1,1])
Elig.phs000297.v1.p1.14
Item
Controls - Case 1: Subjects with controlled hypertension Has outpatient (if possible) measurement of SBP > 140 or DBP > 90 prior to meeting medication criteria OR ICD9 401.* code at any time AND has 1 med from med classes below (and never has more than 1 simultaneous med class, although the med class can change) AND Has all SBP < 135 and DBP < 90 one month AFTER BP meds (require at least 1 BP measurement)
boolean
C1512693 (UMLS CUI [1,1])
C0009932 (UMLS CUI [1,2])
Elig.phs000297.v1.p1.15
Item
Controls - Case 2: Subjects without evidence of hypertension Has no outpatient (if possible) measurement of SBP > 140 or DBP > 90 AND No mention of any anti-hypertensive from med classes below at any time AND Does not have any hypertension ICD9 code: (401, 401.0, 401.9, 402.*, 403.* 404.*)
boolean
C1512693 (UMLS CUI [1,1])
C0009932 (UMLS CUI [1,2])
Elig.phs000297.v1.p1.16
Item
For all controls: Exclude all patients with EF < 35% or with the following ICD9 codes: <th>ICD9 codes</th><th>Description</th> 194.0 MALIGN NEOPL ADRENAL 227.0 BENIGN NEOPLASM ADRENAL 255.0, 255.1, 255.2, 255.3, 255.6, 255.8, 255.9 Disorders of adrenal glands (excludes adrenal insufficiencies - 255.4 and 255.5) 405.* SECONDARY HYPERTENSION 416.* Chronic pulmonary heart disease 581.* Nephrotic syndrome 582.* Chronic glumerulonephritis 745.* Bulbus cordis anomalies 747.1* COARCTATION OF AORTA
boolean
C0009932 (UMLS CUI [1,1])
C0680251 (UMLS CUI [1,2])
Elig.phs000297.v1.p1.18
Item
Subjects with the following codes *are allowable* as controls (no matter when they occurred): <th>ICD9 codes</th><th>Description</th> 242.* Thyrotoxicosis 246 Disorder of thyrocalcitonin secretion 246.8 DISORDERS OF THYROID NEC 246.9 DISORDER OF THYROID NOS 252.8 PARATHYROID DISORDER NEC 252.9 PARATHYROID DISORDER NOS 320.2 ORGANIC SLEEP APNEA 327.21 PRIMARY CENTRAL SLEEP APNEA 327.23 OBSTRUCTIVE SLEEP APNEA 327.27 CEN SLEEP APNEA IN COND CLASS 327.29 OTHER ORGANIC SLEEP APNEA 599.6* OBSTRUCTIVE UROPATHY
boolean
C1512693 (UMLS CUI [1,1])
C0009932 (UMLS CUI [1,2])