Inclusion Criteria
age at least 18
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CD20-positive diffuse large B-cell lymphoma
low-intermediate, high-intermediate or high risk disease and/or bulky tumor (.7.5 cm)
ECOG performance status 0-2.
Exclusion Criteria
prior treatment for diffuse large B-cell lymphoma
types of non-Hodgkin's lymphoma other than DLBCL
CNS involvement of lymphoma.