Healthy male and female subjects of non childbearing potential, 18 to 65 years of age inclusive and in good health

Male and female subjects, 18 to 65 years of age inclusive and having passed screening examinations

Presence of atopic dermatitis confirmed by Itchy skin condition in the past 12 months (must have) Plus three or more of the following: 1. History of involvement of the skin creases 2. Personal history of asthma or hay fever 3. History of generally dry skin in the past year 4. Onset before age of 2 years 5. Visible flexural dermatitis

Diagnosis of at least moderate atopic dermatitis by the IGA and a minimum target area (right or left) situated on the forearm including the antecubital fossa with a corresponding baseline total lesional sign score (TLSS)

Patients with Netherton syndrome, male and female subjects, 18 to 65 years of age inclusive and having passed screening examinations

Confirmed diagnosis of Netherton syndrome (SPINK5 mutation or LEKTI deficiency in the skin)

Minimum total lesional sign score NS (TLSS-NS) of 5-9 for two selected target areas at baseline. The TLSS-NS values need to be similar between the two areas at baseline

History of hypersensitivity to any of the study drugs or to drugs of similar chemical classes or history of serious allergic reaction.

Use of any prescription drugs, herbal supplements, within four (4) weeks prior to initial dosing, and/or over-the-counter (OTC) medication, dietary supplements (vitamins included) within two (2) weeks prior to initial dosing

History of hypersensitivity to any of the study drugs or to drugs of similar chemical classes or history of serious allergic reaction.

History of abnormal skin reactivity to UV light. Unusual exposure to UV light in the previous 3 weeks to study start (screening), including tanning and sun beds

Pregnant or nursing (lactating) women

Women of child-bearing potential must use highly effective contraception (as further defined in study protocol)

Use of topical prescription treatment for eczema within 1 week prior to initial dosing of topical corticosteroids (TCS).

Recent previous treatment with systemic treatment including phototherapy. A washout period will be required for such patients to be eligible to participate in the trial.

History of hypersensitivity to any of the study drugs or to drugs of similar chemical classes or history of serious allergic reaction

History of abnormal skin reactivity to UV light. Unusual exposure to UV light in the previous 3 weeks to study start (screening), including tanning and sun beds

Pregnant or nursing (lactating) women

Women of child-bearing potential must use highly effective contraception (as further defined in study protocol)

Use of topical prescription treatment within 2 week prior to initial dosing of study drug

Recent previous treatment with systemic treatment. A washout period will be required for such patients to be eligible to participate in the trial.

Age

Healthy Subject

Diagnosis

Dermatitis, Atopic

Pruritus

Skin crease

Asthma

Hay fever (Seasonal Allergy)

Dry skin

Onset

Flexural eczema

Allergic reaction, due to correct medicinal substance properly administered

Medication

Dietary Supplements

Ultraviolet Rays

pregnant

Breast feeding, Nursing

Contraception

Topical Corticosteroid

Phototherapy