ID
15581
Beschreibung
Principal Investigator: Luisa Klotz Collaborator: Novartis Information provided by (Responsible Party):University Hospital Muenster -Study to Assess Immune Function and MRI Disease Activity in RRMS Patients When Switching From Natalizumab to Gilenya (ToFingo2) Purpose A trial in patients with relapsing remitting multiple sclerosis (RRMS) Main objectives: •To evaluate changes in the reconstitution of immune surveillance over time upon switching from natalizumab to fingolimod assessed by a change in the expression of CD49d. •To evaluate changes in the migratory capacity of immune cells/peripheral blood mononuclear cells (PBMCs) upon switching from natalizumab to fingolimod in an in-vitro model of the blood-brain-barrier (BBB). •To evaluate changes in paraclinical disease activity over time upon switching from natalizumab to fingolimod assessed by MRI (changes in Gd+, T2w lesions and DTI). •To evaluate changes in T1w / FLAIR lesions upon switching from natalizumab to fingolimod. For further Information please visit https://clinicaltrials.gov/ct2/show/NCT02325440
Link
https://clinicaltrials.gov/ct2/show/NCT02325440
Stichworte
Versionen (1)
- 03.06.16 03.06.16 -
Hochgeladen am
3. Juni 2016
DOI
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Lizenz
Creative Commons BY 4.0
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ToFingo Screening V1 Study relevant assessments NCT02325440
ToFingo Screening V1 Study relevant assessments NCT02325440
- StudyEvent: ODM
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ToFingo Screening V1 Study relevant assessments NCT02325440
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C1317250 (UMLS CUI [1,2])