ID

16661

Description

Short-Term Effects of Medicinal Cannabis Therapy on Spasticity in Multiple Sclerosis; ODM derived from: https://clinicaltrials.gov/show/NCT00248378

Link

https://clinicaltrials.gov/show/NCT00248378

Keywords

  1. 7/30/16 7/30/16 -
Uploaded on

July 30, 2016

DOI

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License

Creative Commons BY 4.0

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Eligibility Multiple Sclerosis NCT00248378

Eligibility Multiple Sclerosis NCT00248378

Inclusion Criteria
clinically definite or probable, laboratory-supported ms
complaints of spasticity and at least moderate increase in tone as evidenced by a score of >= 2 on the modified ashworth scale at either the elbow, hip, or knee
if on disease-modifying therapy ("abc"), have been on a stable dose for at least six months
fluent in english
if not cannabis-naive, must refrain from smoking cannabis for two weeks prior to screening (confirmed by urinalysis)
if on either lioresal (baclofen) or tizanadine (zanaflex), have been on a stable dose for at least three months
>=18 years of age
Exclusion Criteria
axis i psychiatric disorder especially depression or significant neurological disease other than ms as determined by the pi
recent history of active substance abuse defined as daily use for at least 14 days within the past month
drug use restrictions, eg, subjects on probation or parole, employment involving high risk to themselves and/or the public (airline pilot, bus driver, etc.)
any unstable medical health problem
any known pulmonary disorders, including tuberculosis, asthma, or copd
pregnant or nursing
require benzodiazepines to control spasticity
require high doses of analgesic medications on a daily basis

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