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ID
44154
Beschrijving
NCT02641314 Phase 2 Trial of Metronomic Treatment in Children and Adolescents With Recurrent or Progressive Neuroblastoma (NB). The study investigates the tolerance and the efficacy of a new combination of five drugs consisting of propranolol (antiangiogenetic, anti-neuroblastic), Celecoxib (modulating immune response, ant-neuroblastic), cyclophosphamide (antiangiogenetic, anti-neuroblastic), etoposide (antiangiogenetic, anti-neuroblastic), and vinblastin (antiangiogenetic, anti-neuroblastic). Vinblastin is scheduled every 14 days intravenously, all other drugs are applied daily throughout 365 days (except etoposide for 4x3 weeks). The efficacies of each of the drugs have been demonstrated in vitro and in vivo in animal studies. All drugs have been used in children for other conditions. From those experiences low toxicities and a favorable Quality of life are expected. Prof. Dr. Frank Berthold Abt. für Kinderonkologie und –hämatologie Zentrum für Kinder- und Jugendmedizin Universität zu Köln
Trefwoorden
Versies (5)
- 26-12-17 26-12-17 -
- 27-12-17 27-12-17 -
- 15-03-21 15-03-21 - Dr. rer. medic Philipp Neuhaus
- 13-04-21 13-04-21 - Dr. rer. medic Philipp Neuhaus
- 20-09-21 20-09-21 -
Houder van rechten
Universität zu Köln
Geüploaded op
20 september 2021
DOI
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Licentie
Creative Commons BY-NC 3.0
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Metronomic Treatment in Children and Adolescents With Recurrent or Progressive High Risk Neuroblastoma (METRO-NB2012) NCT02641314
Reference
- StudyEvent: Subject Protocol
- Registration
- Medical history
- Baseline
- Therapy and toxicity cycle 1-3
- Therapy and toxicity cycle 4-6
- Therapy and toxicity cycle 7-9
- Therapy and toxicity cycle 10-13
- Therapy and toxicity cycle > 13
- Reference
- Study relevant visits
- Therapeutic response
- End of therapy
- Relapse
- Second malignancy
- Death
- Follow up
Similar models
Reference
- StudyEvent: Subject Protocol
- Registration
- Medical history
- Baseline
- Therapy and toxicity cycle 1-3
- Therapy and toxicity cycle 4-6
- Therapy and toxicity cycle 7-9
- Therapy and toxicity cycle 10-13
- Therapy and toxicity cycle > 13
- Reference
- Study relevant visits
- Therapeutic response
- End of therapy
- Relapse
- Second malignancy
- Death
- Follow up
Name
Type
Description | Question | Decode (Coded Value)
Datatype
Alias
Examination date
Item
Untersuchungsdatum MRT/CT
date
C4038992 (UMLS CUI [1])
Item
Falls MRT gemacht wurde, diese Ergebnisse priorisieren Untersuchungsmethode
integer
C1282548 (UMLS CUI [1])
Code List
Falls MRT gemacht wurde, diese Ergebnisse priorisieren Untersuchungsmethode
CL Item
MRT (1)
C0024485 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
CT (2)
C0040405 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Schädel (1)
C0018670 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Hals (2)
C2228463 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Thorax (3)
C0850563 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Abdomen (4)
C0562238 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Ganzkörper (5)
C1268086 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Wirbelsäule (6)
C0037949 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Sonstige (7)
C0205394 (UMLS CUI-1)
(Comment:de)
(Comment:de)
Anatomic site other
Item
Sonstige Region
text
C1515974 (UMLS CUI [1,1])
C0205394 (UMLS CUI [1,2])
C0205394 (UMLS CUI [1,2])
CL Item
Exzellent (1)
C1961136 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Angemessen (2)
C1548787 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Mangelhaft (3)
(Comment:de)
CL Item
Nicht auswertbar (4)
C1883425 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Adrenal (1)
C0001625 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Abdominal und non-adrenal (2)
C0000726 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Thorakal (3)
C0850563 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Cervikal (4)
C2228463 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Nicht bekannt (5)
C0439673 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Keine Manifestation (6)
C0205319 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
lokoregional (7)
C1947913 (UMLS CUI-1)
(Comment:de)
(Comment:de)
Maximal height of tumor
Item
Tumorhöhe
integer
C1301092 (UMLS CUI [1])
Width of tumor
Item
Tumorbreite
integer
C0487742 (UMLS CUI [1,1])
C0027651 (UMLS CUI [1,2])
C0027651 (UMLS CUI [1,2])
Neoplasms Length
Item
Tumorlänge
integer
C0027651 (UMLS CUI [1,1])
C1444754 (UMLS CUI [1,2])
C1444754 (UMLS CUI [1,2])
CL Item
Nein (1)
C1298908 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Ja (2)
C1298907 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Fraglich (3)
C0459423 (UMLS CUI-1)
(Comment:de)
(Comment:de)
Item
Osteomedulläre Metastasen
integer
C0346979 (UMLS CUI [1])
CL Item
Nein (1)
C1513916 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Ja (2)
C1298907 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Fraglich (3)
C0459423 (UMLS CUI-1)
(Comment:de)
(Comment:de)
Neoplasm Metastasis
Item
Metastasen
boolean
C0027627 (UMLS CUI [1])
CL Item
Nein (1)
C1513916 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Ja (2)
C1298907 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Fraglich (3)
C0459423 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Nein (1)
C1513916 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Ja (2)
C1298907 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Fraglich (3)
C0459423 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Nein (1)
C1513916 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Ja (2)
C1298907 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Fraglich (3)
C0459423 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Nein (1)
C1513916 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Ja (2)
C1298907 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Fraglich (3)
C0459423 (UMLS CUI-1)
(Comment:de)
(Comment:de)
Item
Sonstige Metastasen
integer
C0027627 (UMLS CUI [1,1])
C0205394 (UMLS CUI [1,2])
C0205394 (UMLS CUI [1,2])
CL Item
Nein (1)
CL Item
Ja (2)
CL Item
Fraglich (3)
Comment
Item
Sonstige Bezeichnung
text
C0947611 (UMLS CUI [1])
mIBG
Item
Datum der Untersuchung
date
C2229074 (UMLS CUI [1,1])
C0011008 (UMLS CUI [1,2])
C0011008 (UMLS CUI [1,2])
CL Item
Exzellent (1)
C1961136 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Angemessen (2)
C1548787 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Mangelhaft (3)
(Comment:de)
CL Item
Nicht auswertbar (4)
C1883425 (UMLS CUI-1)
(Comment:de)
(Comment:de)
Item
mIBG Aufnahme Primärtumor (PT)
integer
C0047506 (UMLS CUI [1,1])
C0677930 (UMLS CUI [1,2])
C0677930 (UMLS CUI [1,2])
CL Item
Nein (1)
CL Item
Ja (2)
CL Item
Fraglich (3)
Item
Intensität PT (im Vegleich zu Leber)
integer
C0871362 (UMLS CUI [1,1])
C0677930 (UMLS CUI [1,2])
C0677930 (UMLS CUI [1,2])
CL Item
0 (1)
CL Item
1 (2)
CL Item
2 (3)
CL Item
3 (4)
CL Item
Homogen (1)
C1881065 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Heterogen (2)
C1512426 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Kalte Herde (3)
(Comment:de)
CL Item
Ringförmige Ausdehnung (4)
(Comment:de)
Item
mIBG Aufnahme Metastasen
integer
C0047506 (UMLS CUI [1,1])
C0027627 (UMLS CUI [1,2])
C0027627 (UMLS CUI [1,2])
CL Item
Nein (1)
C1513916 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Ja (2)
C1298907 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Fraglich (3)
C0459423 (UMLS CUI-1)
(Comment:de)
(Comment:de)
Neoplasm Metastasis of bone marrow
Item
Osteomedulläre Metastasen vorhanden?
boolean
C0346979 (UMLS CUI [1])
Score
Item
Kum. Score
integer
C0449820 (UMLS CUI [1])
liver metatsis
Item
Path. Anreicherung Leberherde
boolean
C0426686 (UMLS CUI [1])
Soft tissue
Item
Path. Anreicherung Weichteilherde
boolean
C0037578 (UMLS CUI [1])
SIOPEN Score
Item
SIOPEN Score
integer
C0027819 (UMLS CUI [1,1])
C0449820 (UMLS CUI [1,2])
C0449820 (UMLS CUI [1,2])
Bone marrow Examination Date
Item
Datum der KM-Untersuchung
date
C0005953 (UMLS CUI [1,1])
C2826643 (UMLS CUI [1,2])
C2826643 (UMLS CUI [1,2])
Cytology
Item
Zytologie durchgeführt
boolean
C1305671 (UMLS CUI [1])
Item
Zytologie: KM-Infiltrationsgrad
text
C3854434 (UMLS CUI [1,1])
C0010819 (UMLS CUI [1,2])
C0332448 (UMLS CUI [1,3])
C0010819 (UMLS CUI [1,2])
C0332448 (UMLS CUI [1,3])
CL Item
Nicht nachweisbar (1)
(Comment:de)
CL Item
> 1 - 10 % (3)
(Comment:de)
CL Item
> 10 - 30 % (4)
(Comment:de)
CL Item
> 30 - 100 % (5)
(Comment:de)
CL Item
Nicht auswertbar (6)
(Comment:de)
CL Item
< 1 % (< 1)
(Comment:de)
Immunocytochemistry
Item
Immunzytochemie durchgeführt
boolean
C0242349 (UMLS CUI [1])
Item
Immunzytochemie: KM Infiltrationsgrad
integer
C0242349 (UMLS CUI [1,1])
C3854434 (UMLS CUI [1,2])
C3854434 (UMLS CUI [1,2])
CL Item
Nicht nachweisbar (1)
CL Item
< 1 % (2)
CL Item
> 1 - 10 % (3)
CL Item
> 10 - 30 % (4)
CL Item
> 30 - 100 % (5)
CL Item
Nicht auswertbar (6)
PCR
Item
PCR durchgeführt?
boolean
C0032520 (UMLS CUI [1])
CL Item
Positiv (1)
C1446409 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Negativ (2)
C0205160 (UMLS CUI-1)
(Comment:de)
(Comment:de)
Item
Genauere Angabe zum PCR Ergebnis
text
C0032520 (UMLS CUI [1,1])
C0032520 (UMLS CUI [1,2])
C0947611 (UMLS CUI [1,3])
C0032520 (UMLS CUI [1,2])
C0947611 (UMLS CUI [1,3])
Examination date other method
Item
Untersuchungsdatum sonstige Methode
date
C2826643 (UMLS CUI [1])
Examination method
Item
Spezifizierung sonstige Untersuchungsmethode
text
C1282548 (UMLS CUI [1])
CL Item
Positiv (1)
CL Item
Negativ (2)
Item
Befund osteomedulläre Metastasen
integer
C0153690 (UMLS CUI [1,1])
C0243095 (UMLS CUI [1,2])
C0243095 (UMLS CUI [1,2])
CL Item
Positiv (1)
CL Item
Negativ (2)
Item
Befund Fernlymphknoten
integer
C0686619 (UMLS CUI [1])
CL Item
Positiv (1)
CL Item
Negativ (2)
CL Item
Positiv (1)
CL Item
Negativ (2)
CL Item
Positiv (1)
CL Item
Negativ (2)
Item
Befund ZNS
integer
C3714787 (UMLS CUI [1,1])
C0243095 (UMLS CUI [1,2])
C0243095 (UMLS CUI [1,2])
CL Item
Positiv (1)
CL Item
Negativ (2)
Item
Befund sonstige Metastasen
integer
C0027627 (UMLS CUI [1,1])
C0205394 (UMLS CUI [1,2])
C1335151 (UMLS CUI [1,3])
C0205394 (UMLS CUI [1,2])
C1335151 (UMLS CUI [1,3])
CL Item
Positiv (1)
CL Item
Negativ (2)
Specify other neoplasm metastasis
Item
Spezifizierung sonstiger Metastasen
text
C1521902 (UMLS CUI [1,1])
C0027627 (UMLS CUI [1,2])
C0205394 (UMLS CUI [1,3])
C0027627 (UMLS CUI [1,2])
C0205394 (UMLS CUI [1,3])
Item
Remissionsstatus (Gesamtbeurteilung)
integer
C0544452 (UMLS CUI [1,1])
C0449438 (UMLS CUI [1,2])
C0449438 (UMLS CUI [1,2])
CL Item
CR (1)
C0677874 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Keine CR (2)
C1298908 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Nicht auswertbar (6)
C1883425 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Komplette Remission (CR)
C0677874 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Sehr gute partielle Remission (VGPR)
C4053871 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Partielle Remission (PR)
C1275833 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Unverändert (SD)
C0442739 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Progression (PD)
C0242656 (UMLS CUI-1)
(Comment:de)
(Comment:de)
Target sum
Item
Target Summe
integer
C1515051 (UMLS CUI [1])
CL Item
Rezidiv (4)
(Comment:de)
CL Item
Sonstiger Zeitpunkt (5)
(Comment:de)
CL Item
Nach 6 Monaten (V1)
(Comment:de)
CL Item
12 Monate oder EOT gemäß Protokoll (V2)
(Comment:de)
CL Item
Therapieende nicht gemäß Protokoll (EOT)
(Comment:de)
Time other
Item
Sonstiger Zeitpunkt
text
C0040223 (UMLS CUI [1])
MRT / CT
Item
MRT/CT durchgeführt?
boolean
C0024485 (UMLS CUI [1,1])
C0040405 (UMLS CUI [1,2])
C0040405 (UMLS CUI [1,2])
3-Iodobenzylguanidine
Item
mIBG durchgeführt?
boolean
C0047506 (UMLS CUI [1])
Bone Marrow Examination
Item
Knochenmark untersucht?
boolean
C0005957 (UMLS CUI [1])
Other specified examination
Item
Sonstige Untersuchungen durchgeführt?
boolean
C0260879 (UMLS CUI [1])
Examination date
Item
Nur von Studienzentrale auszufüllen Untersuchungsdatum MRT/CT
date
C2826643 (UMLS CUI [1])
Item
Falls MRT gemacht wurde, diese Ergebnisse priorisieren Untersuchungsmethode
integer
C2911685 (UMLS CUI [1])
CL Item
MRT (1)
CL Item
CT (2)
CL Item
Exzellent (1)
C1961136 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Angemessen (2)
C1548787 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Mangelhaft (3)
(Comment:de)
CL Item
Nicht auswertbar (4)
C1883425 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Adrenal (1)
C0001625 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Abdominal und non-adrenal (2)
C0000726 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Thorakal (3)
C0850563 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Cervikal (4)
C2228463 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Nicht bekannt (5)
C0439673 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Keine Manifestation (6)
C1280464 (UMLS CUI-1)
C0684336 (UMLS CUI-2)
(Comment:de)
C0684336 (UMLS CUI-2)
(Comment:de)
CL Item
lokoregional (7)
C1947913 (UMLS CUI-1)
(Comment:de)
(Comment:de)
tumor height
Item
Tumorhöhe
integer
C1301092 (UMLS CUI [1])
Neoplasms Width
Item
Tumorbreite
integer
C0487742 (UMLS CUI [1,1])
C0027651 (UMLS CUI [1,2])
C0027651 (UMLS CUI [1,2])
Tumor length
Item
Tumorlänge
integer
C0006826 (UMLS CUI [1,1])
C1444754 (UMLS CUI [1,2])
C1444754 (UMLS CUI [1,2])
Target sum
Item
Target Summe
integer
C1515051 (UMLS CUI [1])
Contrast Media
Item
Kontrastmedium aufgenommen?
boolean
C0807938 (UMLS CUI [1])
Neoplasm Metastasis
Item
Metastasen
boolean
C0027627 (UMLS CUI [1])
Secondary malignant neoplasm of bone marrow
Item
Osteomedulläre Metastasen
boolean
C0346979 (UMLS CUI [1])
Secondary malignant neoplasm of lymph node
Item
Fernlymphknoten (LK)
boolean
C0686619 (UMLS CUI [1])
Number of lymph nodes involved by malignant neoplasm
Item
Anzahl an beteiligten Regionen mit LK
integer
C2732750 (UMLS CUI [1])
Secondary malignant neoplasm of liver
Item
Leber
boolean
C0494165 (UMLS CUI [1])
Quanity metastasis
Item
Anzahl an Lebermetastasen
integer
C0494165 (UMLS CUI [1,1])
C0027627 (UMLS CUI [1,2])
C0027627 (UMLS CUI [1,2])
Skin
Item
Haut
boolean
C1123023 (UMLS CUI [1])
CNS
Item
ZNS
boolean
C3714787 (UMLS CUI [1])
Other
Item
Sonstige
boolean
C0205394 (UMLS CUI [1])
Examination date
Item
Datum der Untersuchung
date
C2826643 (UMLS CUI [1])
CL Item
Exzellent (1)
CL Item
Angemessen (2)
CL Item
Mangelhaft (3)
CL Item
Nicht auswertbar (4)
3-Iodobenzylguanidine Neoplasm Metastasis
Item
mIBG Aufnahme Primärtumor (PT)
boolean
C0047506 (UMLS CUI [1,1])
C0027627 (UMLS CUI [1,2])
C0027627 (UMLS CUI [1,2])
signal intensity; primary tumor
Item
Intensität PT (im Vegleich zu Leber)
integer
C0871362 (UMLS CUI [1,1])
C0677930 (UMLS CUI [1,2])
C0677930 (UMLS CUI [1,2])
Item
Aufnahmemuster PT
integer
C0677930 (UMLS CUI [1,1])
C0005891 (UMLS CUI [1,2])
C0005891 (UMLS CUI [1,2])
CL Item
Homogen (1)
C1881065 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Heterogen (2)
C1512426 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Kalte Herde (3)
C0221198 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Ringförmige Ausdehnung (4)
C0475437 (UMLS CUI-1)
(Comment:de)
(Comment:de)
3-Iodobenzylguanidine neoplasm metastasis
Item
mIBG Aufnahme Metastasen
boolean
C0047506 (UMLS CUI [1,1])
C0027627 (UMLS CUI [1,2])
C0027627 (UMLS CUI [1,2])
Bone marrow metastasis
Item
Osteomedulläre Metastasen vorhanden?
boolean
C0346979 (UMLS CUI [1])
Score
Item
Kum. Score
integer
C0449820 (UMLS CUI [1])
Liver finding
Item
Path. Anreicherung Leberherde
boolean
C0426686 (UMLS CUI [1])
Soft Tissue Injuries
Item
Path. Anreicherung Weichteilherde
boolean
C0037578 (UMLS CUI [1])
Neuroblastoma Score
Item
SIOPEN Score (wenn verfügbar)
integer
C0027819 (UMLS CUI [1,1])
C0449820 (UMLS CUI [1,2])
C0449820 (UMLS CUI [1,2])
Bone Marrow Examination Date
Item
Datum der KM-Untersuchung
integer
C0005953 (UMLS CUI [1,1])
C2826643 (UMLS CUI [1,2])
C2826643 (UMLS CUI [1,2])
Cytology procedure
Item
Zytologie durchgeführt
boolean
C1305671 (UMLS CUI [1])
Item
Zytologie: KM-Infiltrationsgrad
integer
C3854434 (UMLS CUI [1,1])
C0010819 (UMLS CUI [1,2])
C0332448 (UMLS CUI [1,3])
C0010819 (UMLS CUI [1,2])
C0332448 (UMLS CUI [1,3])
CL Item
Nicht nachweisbar (1)
CL Item
< 1 % (2)
CL Item
> 1 - 10 % (3)
CL Item
> 10 - 30 % (4)
CL Item
> 30 - 100 % (5)
Immunocytochemistry
Item
Immunzytochemie durchgeführt
boolean
C0242349 (UMLS CUI [1])
Item
Immunzytochemie: KM Infiltrationsgrad
integer
C0242349 (UMLS CUI [1,1])
C3854434 (UMLS CUI [1,2])
C3854434 (UMLS CUI [1,2])
CL Item
Nicht nachweisbar (1)
CL Item
< 1 % (2)
CL Item
> 1 - 10 % (3)
CL Item
> 10 - 30 % (4)
CL Item
> 30 - 100 % (5)
CL Item
Nicht auswertbar (6)
PCR
Item
PCR durchgeführt?
boolean
CL Item
Positiv (1)
CL Item
Negativ (2)
Polymerase Chain Reaction Comment
Item
Genauere Angabe zum PCR Ergebnis
text
C0032520 (UMLS CUI [1,1])
C0947611 (UMLS CUI [1,2])
C0947611 (UMLS CUI [1,2])
Examination Date
Item
Untersuchungsdatum sonstige Methode
date
C2826643 (UMLS CUI [1])
Examination by method To specify
Item
Spezifizierung sonstige Untersuchungsmethode
text
C1282548 (UMLS CUI [1,1])
C1521902 (UMLS CUI [1,2])
C1521902 (UMLS CUI [1,2])
CL Item
Positiv (1)
CL Item
Negativ (2)
Item
Befund osteomedulläre Metastasen
integer
C0153690 (UMLS CUI [1,1])
C0243095 (UMLS CUI [1,2])
C0243095 (UMLS CUI [1,2])
CL Item
Positiv (1)
CL Item
Negativ (2)
Item
Befund Fernlymphknoten
integer
C0243095 (UMLS CUI [1,1])
C3830456 (UMLS CUI [1,2])
C3830456 (UMLS CUI [1,2])
CL Item
Positiv (1)
CL Item
Negativ (2)
CL Item
Positiv (1)
CL Item
Negativ (2)
CL Item
Positiv (1)
CL Item
Negativ (2)
Item
Befund ZNS
integer
C3714787 (UMLS CUI [1,1])
C0243095 (UMLS CUI [1,2])
C0243095 (UMLS CUI [1,2])
CL Item
Positiv (1)
CL Item
Negativ (2)
Item
Befund sonstige Metastasen
integer
C0027627 (UMLS CUI [1,1])
C1335151 (UMLS CUI [1,2])
C1335151 (UMLS CUI [1,2])
CL Item
Positiv (1)
CL Item
Negativ (2)
Neoplasm Metastasis Other
Item
Spezifizierung sonstiger Metastasen
text
C1521902 (UMLS CUI [1,1])
C0027627 (UMLS CUI [1,2])
C0027627 (UMLS CUI [1,2])
CL Item
Nicht auswertbar (5)
C1883425 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Komplette Remission (CR )
C0677874 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Partielle Remission (PR)
C4053871 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Unverändert (SD)
C0677946 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Progression (PD)
C0242656 (UMLS CUI-1)
(Comment:de)
(Comment:de)
Item
Remissionsstatus nach mIBG
text
C1704632 (UMLS CUI [1,1])
C0047506 (UMLS CUI [1,2])
C0047506 (UMLS CUI [1,2])
CL Item
Nicht auswertbar (5)
C1883425 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Partielle Remission (PR)
C4053871 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Unverändert (SD)
C0677946 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Progression (PD)
C0242656 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Komplette Remission (CR)
Item
Remissionsstatus nach KM
text
C1704632 (UMLS CUI [1,1])
C0009924 (UMLS CUI [1,2])
C0009924 (UMLS CUI [1,2])
CL Item
Nicht auswertbar (5)
C1883425 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Partielle Remission (PR)
C4053871 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Unverändert (SD)
C0677946 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Progression (PD)
C0242656 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Komplette Remission (CR)
Sum
Item
Target Summe (nach RECIST)
integer
C1515051 (UMLS CUI [1])
Item
Remissionsstatus (Gesamtbeurteilung)
integer
C0544452 (UMLS CUI [1,1])
C0449438 (UMLS CUI [1,2])
C0449438 (UMLS CUI [1,2])
CL Item
Progression (4)
C0242656 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Nicht auswertbar (5)
C1883425 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Komplette Remission (CR)
C0677874 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Partielle Remission (PR)
C1275833 (UMLS CUI-1)
(Comment:de)
(Comment:de)
CL Item
Unverändert (SD)
C0677946 (UMLS CUI-1)
(Comment:de)
(Comment:de)
Date
Item
Date
date
C0011008 (UMLS CUI [1])
Investigator name
Item
Investigator name
text
C2826892 (UMLS CUI [1])
Investigator signature
Item
Investigator signature
text
C2346576 (UMLS CUI [1])