ID
44181
Beschrijving
PART B - Period 1 - Day 1 - Ropinirole and the effect of food in early stage Parkinson’s disease subjects 101468/164 Study ID: 101468/164 Clinical Study ID: 101468/164 Study Title: An open-label, randomised, two part study to investigate the relative bioavailability of Ropinirole new and standard, marketed formulations and the effect of food on the pharmacokinetics of Ropinirole new formulation in early stage Parkinson’s disease subjects Patient Level Data: Study Listed on ClinicalStudyDataRequest.com Clinicaltrials.gov Identifier: Sponsor: GlaxoSmithKline Collaborators: N/A Phase: phase 1 Study Recruitment Status: Completed Generic Name: ropinirole Trade Name: Modutab,ZIPEREVE,ZEPREVE,REPREVE,ADARTREL,REQUIP,Zygara; Zygara,ZIPEREVE,ZEPREVE,Requip Depot,REQUIP,REPREVE,Modutab,ADARTREL Study Indication: Restless Legs Syndrome
Trefwoorden
Versies (3)
- 03-10-17 03-10-17 -
- 13-04-21 13-04-21 - Dr. rer. medic Philipp Neuhaus
- 20-09-21 20-09-21 -
Houder van rechten
glaxoSmithKline
Geüploaded op
20 september 2021
DOI
Voor een aanvraag inloggen.
Licentie
Creative Commons BY-NC 3.0
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PART B - Period 1 - Day 1 - Ropinirole and the effect of food in early stage Parkinson’s disease subjects 101468/164
PART B - Period 1 - Day 1 - Ropinirole and the effect of food in early stage Parkinson’s disease subjects 101468/164
Beschrijving
Inclusion Criteria
Alias
- UMLS CUI-1
- C1512693
Beschrijving
age and child-bearing potential contraception
Datatype
boolean
Alias
- UMLS CUI [1,1]
- C0001779
- UMLS CUI [1,2]
- C1960468
- UMLS CUI [1,3]
- C0700589
Beschrijving
idiopathic Parkinson's disease Hoehn&Yahr Stage
Datatype
boolean
Alias
- UMLS CUI [1,1]
- C0865475
- UMLS CUI [1,2]
- C3639483
Beschrijving
study subject participation status ropinirole or candidate for dopaminergic therapy
Datatype
boolean
Alias
- UMLS CUI [1,1]
- C2348568
- UMLS CUI [1,2]
- C0244821
- UMLS CUI [2]
- C3267134
Beschrijving
bmi
Datatype
boolean
Alias
- UMLS CUI [1]
- C1305855
Beschrijving
informed consent
Datatype
boolean
Alias
- UMLS CUI [1]
- C0021430
Beschrijving
drug dosing ropinirole
Datatype
boolean
Alias
- UMLS CUI [1,1]
- C0244821
- UMLS CUI [1,2]
- C0678766
Beschrijving
exemption approved
Datatype
boolean
Alias
- UMLS CUI [1,1]
- C0585836
- UMLS CUI [1,2]
- C1708968
Beschrijving
Medical monitor name
Datatype
text
Alias
- UMLS CUI [1,1]
- C0027365
- UMLS CUI [1,2]
- C1708968
Beschrijving
Date of approval
Datatype
date
Alias
- UMLS CUI [1]
- C2346844
Beschrijving
Exclusion Criteria
Alias
- UMLS CUI-1
- C0680251
Beschrijving
physical examination abnormality
Datatype
boolean
Alias
- UMLS CUI [1,1]
- C0031809
- UMLS CUI [1,2]
- C1704258
- UMLS CUI [2]
- C0035648
Beschrijving
psychiatric, haematological, renal, hepatic, endocrinological, neurological, or cardiovascular disease or active malignancy
Datatype
boolean
Alias
- UMLS CUI [1]
- C0004936
- UMLS CUI [2]
- C0018939
- UMLS CUI [3]
- C0022658
- UMLS CUI [4]
- C0023895
- UMLS CUI [5,1]
- C0014130
- UMLS CUI [5,2]
- C0027765
- UMLS CUI [6]
- C0007222
- UMLS CUI [7]
- C0006826
Beschrijving
laboratory abnormality or ECG abnormalities
Datatype
boolean
Alias
- UMLS CUI [1]
- C0438215
- UMLS CUI [2]
- C0522055
Beschrijving
Hepatitis B surface antigen, Hepatitis C antibody and HIV antibody
Datatype
boolean
Alias
- UMLS CUI [1,1]
- C0019168
- UMLS CUI [1,2]
- C0166049
- UMLS CUI [2]
- C0019683
Beschrijving
alcohol breath test or blood test and/or urine drugs of abuse test at screening
Datatype
boolean
Alias
- UMLS CUI [1,1]
- C0202306
- UMLS CUI [1,2]
- C1710477
- UMLS CUI [1,3]
- C1167994
- UMLS CUI [1,4]
- C1710477
- UMLS CUI [2,1]
- C0451130
- UMLS CUI [2,2]
- C1710477
Beschrijving
syncope or orthostatic hypotension
Datatype
boolean
Alias
- UMLS CUI [1]
- C0020651
- UMLS CUI [2,1]
- C0039070
- UMLS CUI [2,2]
- C0262926
Beschrijving
sleep disorder or Epworth Sleep Score 39
Datatype
boolean
Alias
- UMLS CUI [1,1]
- C0851578
- UMLS CUI [1,2]
- C2129304
Beschrijving
Abnormal diastolic arterial pressure or abnormal systolic arterial pressure
Datatype
boolean
Alias
- UMLS CUI [1]
- C0277888
- UMLS CUI [2]
- C0277883
Beschrijving
L-dopa treatment must be discontinued for at least a 2-week wash-out period prior to dosing with study medication
Datatype
boolean
Alias
- UMLS CUI [1,1]
- C0013227
- UMLS CUI [1,2]
- C0023570
Beschrijving
Note: Patients on dopaminergic agonists other than ropinirole CR may be enrolled if the agent is stopped for a 2-week wash-out period prior to enrolment. Patients on selegiline, amantadine, or anticholinergics may be enrolled but must have been on a stable dose for at least one month prior to study enrolment and must remain on their current dose throughout the treatment phase of the study
Datatype
boolean
Alias
- UMLS CUI [1,1]
- C0013036
- UMLS CUI [1,2]
- C3469597
- UMLS CUI [1,3]
- C0262926
Beschrijving
hormone replacement therapy or CYP1A2 inhibitors or inducers
Datatype
boolean
Alias
- UMLS CUI [1]
- C3850050
- UMLS CUI [2]
- C3850068
- UMLS CUI [3]
- C0282402
Beschrijving
Blood donation or significant blood loss
Datatype
boolean
Alias
- UMLS CUI [1]
- C0005795
- UMLS CUI [2]
- C3163616
Beschrijving
personal history, or family history, of adverse reactions or hypersensitivity to ropinirole
Datatype
boolean
Alias
- UMLS CUI [1,1]
- C0020517
- UMLS CUI [1,2]
- C0244821
- UMLS CUI [1,3]
- C0241889
- UMLS CUI [1,4]
- C0559546
- UMLS CUI [1,5]
- C0244821
- UMLS CUI [1,6]
- C0241889
- UMLS CUI [2,1]
- C0020517
- UMLS CUI [2,2]
- C0244821
- UMLS CUI [2,3]
- C0332119
- UMLS CUI [3,1]
- C0559546
- UMLS CUI [3,2]
- C0244821
- UMLS CUI [3,3]
- C0332119
Beschrijving
Use of any investigational drug
Datatype
boolean
Alias
- UMLS CUI [1]
- C0013230
Beschrijving
over-the-counter (OTC) medicine
Datatype
boolean
Alias
- UMLS CUI [1,1]
- C2709201
- UMLS CUI [1,2]
- C0013227
Beschrijving
With alcohol abuse defined as an average weekly intake of greater than 21 units or an average daily intake of greater than 3 units for men; greater than 14 units per week or greater than 2 units per day for women. One unit is equivalent to half a pint of beer, one measure of spirits, or one glass of wine.
Datatype
boolean
Alias
- UMLS CUI [1,1]
- C1510472
- UMLS CUI [1,2]
- C0085762
Beschrijving
drop out of the study prematurely or requirement of prohibited concomitant medication or non compliant behaviour
Datatype
boolean
Alias
- UMLS CUI [1,1]
- C2347852
- UMLS CUI [1,2]
- C2348568
- UMLS CUI [1,3]
- C1321605
Beschrijving
pregnant or breast-feeding
Datatype
boolean
Alias
- UMLS CUI [1,1]
- C0032961
- UMLS CUI [1,2]
- C0006147
Beschrijving
exemption approved
Datatype
boolean
Alias
- UMLS CUI [1,1]
- C0585836
- UMLS CUI [1,2]
- C1708968
Beschrijving
Medical monitor name
Datatype
text
Alias
- UMLS CUI [1,1]
- C0027365
- UMLS CUI [1,2]
- C1708968
Beschrijving
Date of approval
Datatype
date
Alias
- UMLS CUI [1]
- C2346844
Beschrijving
Physical examination
Alias
- UMLS CUI-1
- C0031809
Beschrijving
Body system
Datatype
integer
Alias
- UMLS CUI [1,1]
- C1268086
- UMLS CUI [1,2]
- C0449913
Beschrijving
Body system abnormality
Datatype
integer
Alias
- UMLS CUI [1,1]
- C0460002
- UMLS CUI [1,2]
- C1704258
Beschrijving
Describe abnormality body system
Datatype
text
Alias
- UMLS CUI [1,1]
- C0459424
- UMLS CUI [1,2]
- C0031809
- UMLS CUI [1,3]
- C0678257
Beschrijving
Pregnancy test
Alias
- UMLS CUI-1
- C0032976
Beschrijving
pregnancy test
Datatype
integer
Alias
- UMLS CUI [1]
- C0032976
Beschrijving
pregnancy test
Datatype
integer
Alias
- UMLS CUI [1]
- C0032976
Beschrijving
Date of pregnancy test
Datatype
date
Alias
- UMLS CUI [1,1]
- C0032976
- UMLS CUI [1,2]
- C0011008
Beschrijving
Result of pregnancy test
Datatype
integer
Alias
- UMLS CUI [1]
- C0427777
Beschrijving
Alcohol breath/ blood test
Alias
- UMLS CUI-1
- C0202304
Beschrijving
Perform Alcohol Breath/Blood Test and attach printout
Datatype
time
Alias
- UMLS CUI [1,1]
- C0202304
- UMLS CUI [1,2]
- C0040223
Beschrijving
Result of alcohol test
Datatype
integer
Alias
- UMLS CUI [1,1]
- C0202304
- UMLS CUI [1,2]
- C1274040
Beschrijving
alcohol consumption
Datatype
boolean
Alias
- UMLS CUI [1,1]
- C0001948
- UMLS CUI [1,2]
- C0443288
Beschrijving
Drug screening (urine)
Alias
- UMLS CUI-1
- C0202274
Beschrijving
Time of drug screening
Datatype
time
Alias
- UMLS CUI [1,1]
- C0040223
- UMLS CUI [1,2]
- C0202274
Beschrijving
Cannabinoids urine
Datatype
integer
Alias
- UMLS CUI [1,1]
- C0202274
- UMLS CUI [1,2]
- C0006864
Beschrijving
Morphine and morphine derivates urine
Datatype
integer
Alias
- UMLS CUI [1,1]
- C0202274
- UMLS CUI [1,2]
- C0279996
Beschrijving
Amphetamine urine
Datatype
integer
Alias
- UMLS CUI [1,1]
- C0202274
- UMLS CUI [1,2]
- C0002667
Beschrijving
Barbiturates urine
Datatype
integer
Alias
- UMLS CUI [1,1]
- C0202274
- UMLS CUI [1,2]
- C0004745
Beschrijving
Benzodiazepines urine
Datatype
integer
Alias
- UMLS CUI [1,1]
- C0202274
- UMLS CUI [1,2]
- C0005064
Beschrijving
Cocaine urine
Datatype
integer
Alias
- UMLS CUI [1,1]
- C0202274
- UMLS CUI [1,2]
- C0009170
Beschrijving
Tricyclic antidepressants urine
Datatype
integer
Alias
- UMLS CUI [1]
- C0003290
Beschrijving
Urine drug screening positive specify
Datatype
text
Alias
- UMLS CUI [1,1]
- C2711519
- UMLS CUI [1,2]
- C1521902
Beschrijving
Orthostatic blood pressure / Pulse - Predose
Alias
- UMLS CUI-1
- C0518766
- UMLS CUI-2
- C1095971
- UMLS CUI-3
- C0232117
- UMLS CUI-4
- C3812758
Beschrijving
For the pre-dose measurements in Part A, Day 1 of Periods 1 and 2, and Part B, Day 1 of Periods 1 and 2, 3 sets of semi-supine and erect blood pressure and pulse measurements will be taken, commencing approximately 40 minutes prior to dosing and each set will be separated by 10 minutes rest in the semi- supine position. Three stable measurements should be recorded In this instance stable is defined as the three semi-supine diastolic measurements being within 15 mmHg of the lowest measurement. This rule also applies for the semi-supine systolic and erect systolic and diastolic measurements. A maximum of six attempts can be made to obtain measurements pre-dose. If three consecutive stable measurements of blood pressure cannot be obtained then the Investigator should contact the Medical Monitor to discuss whether the patient can be included/continue in the study.
Datatype
date
Alias
- UMLS CUI [1,1]
- C1320303
- UMLS CUI [1,2]
- C3812758
Beschrijving
Heart rate Semi-Supine
Datatype
integer
Maateenheden
- bpm
Alias
- UMLS CUI [1,1]
- C0018810
- UMLS CUI [1,2]
- C0038846
- UMLS CUI [1,3]
- C3812758
Beschrijving
Heart Rate standing
Datatype
integer
Maateenheden
- bpm
Alias
- UMLS CUI [1,1]
- C2029905
- UMLS CUI [1,2]
- C3812758
Beschrijving
Systolic blood pressure semi-supine
Datatype
integer
Maateenheden
- mmHg
Alias
- UMLS CUI [1,1]
- C0871470
- UMLS CUI [1,2]
- C0038846
- UMLS CUI [1,3]
- C3812758
Beschrijving
Diastolic blood pressure semi-supine
Datatype
integer
Maateenheden
- mmHg
Alias
- UMLS CUI [1,1]
- C0428883
- UMLS CUI [1,2]
- C0038846
- UMLS CUI [1,3]
- C3812758
Beschrijving
Systolic blood pressure standing
Datatype
integer
Maateenheden
- mmHg
Alias
- UMLS CUI [1,1]
- C0871470
- UMLS CUI [1,2]
- C0231472
- UMLS CUI [1,3]
- C3812758
Beschrijving
Diastolic blood pressure standing
Datatype
integer
Maateenheden
- mmHg
Alias
- UMLS CUI [1,1]
- C1303019
- UMLS CUI [1,2]
- C3812758
Beschrijving
Concomitant medication
Alias
- UMLS CUI-1
- C2347852
Beschrijving
If 'Yes', please document on the Concomitant Medication Report Forms.
Datatype
integer
Alias
- UMLS CUI [1]
- C0580105
Beschrijving
tobacco use unchanged
Datatype
integer
Alias
- UMLS CUI [1,1]
- C0543414
- UMLS CUI [1,2]
- C0442739
Beschrijving
dietary restrictions
Datatype
integer
Alias
- UMLS CUI [1,1]
- C0425422
- UMLS CUI [1,2]
- C1321605
Beschrijving
Adverse event
Alias
- UMLS CUI-1
- C0877248
Beschrijving
Patient diary
Alias
- UMLS CUI-1
- C3890583
Beschrijving
Patient diary
Datatype
text
Alias
- UMLS CUI [1]
- C3890583
Beschrijving
Randomization
Alias
- UMLS CUI-1
- C0034656
Beschrijving
study subject participation status eligibility
Datatype
boolean
Alias
- UMLS CUI [1,1]
- C2348568
- UMLS CUI [1,2]
- C0013893
Beschrijving
Randomization
Datatype
integer
Alias
- UMLS CUI [1,1]
- C0034656
- UMLS CUI [1,2]
- C1522541
Beschrijving
High fat breakfast
Alias
- UMLS CUI-1
- C2698559
- UMLS CUI-2
- C0521974
Beschrijving
High fat breakfast started
Datatype
time
Alias
- UMLS CUI [1,1]
- C2698559
- UMLS CUI [1,2]
- C0521974
- UMLS CUI [1,3]
- C0439659
Beschrijving
The suggested time for breakfast is 20 minutes
Datatype
time
Alias
- UMLS CUI [1,1]
- C2698559
- UMLS CUI [1,2]
- C0521974
- UMLS CUI [1,3]
- C0444930
Beschrijving
Breakfast completed
Datatype
integer
Alias
- UMLS CUI [1,1]
- C0814440
- UMLS CUI [1,2]
- C0205197
Beschrijving
Breakfast not completed comment
Datatype
text
Alias
- UMLS CUI [1,1]
- C0947611
- UMLS CUI [1,2]
- C0814440
- UMLS CUI [1,3]
- C0205197
Beschrijving
Study Drug Dosing
Alias
- UMLS CUI-1
- C0013175
- UMLS CUI-2
- C0678766
Beschrijving
The subject will not be allowed to lie down or sleep for 4 hours after the morning dose
Datatype
time
Maateenheden
- 24hr:min
Alias
- UMLS CUI [1,1]
- C0178602
- UMLS CUI [1,2]
- C0040223
Beschrijving
Witness 1
Datatype
text
Alias
- UMLS CUI [1,1]
- C0682356
- UMLS CUI [1,2]
- C0001555
Beschrijving
Witness date 1
Datatype
date
Alias
- UMLS CUI [1,1]
- C4263486
- UMLS CUI [1,2]
- C0011008
Beschrijving
Witness 2
Datatype
text
Alias
- UMLS CUI [1,1]
- C0682356
- UMLS CUI [1,2]
- C0001555
Beschrijving
Witness date 2
Datatype
date
Alias
- UMLS CUI [1,1]
- C4263486
- UMLS CUI [1,2]
- C0011008
Beschrijving
Orthostatic blood pressure / pulse measurement - post dose
Alias
- UMLS CUI-1
- C1095971
- UMLS CUI-2
- C0232117
- UMLS CUI-3
- C0439568
Beschrijving
Date of visit
Datatype
date
Alias
- UMLS CUI [1]
- C1320303
Beschrijving
Post dose
Datatype
integer
Alias
- UMLS CUI [1]
- C0439568
Beschrijving
Time post dose
Datatype
time
Alias
- UMLS CUI [1,1]
- C0439568
- UMLS CUI [1,2]
- C0040223
Beschrijving
Heart rate Semi-Supine
Datatype
integer
Maateenheden
- bpm
Alias
- UMLS CUI [1,1]
- C0018810
- UMLS CUI [1,2]
- C0038846
- UMLS CUI [1,3]
- C0439568
Beschrijving
Heart Rate standing
Datatype
integer
Maateenheden
- bpm
Alias
- UMLS CUI [1,1]
- C2029905
- UMLS CUI [1,2]
- C0439568
Beschrijving
Systolic blood pressure semi-supine
Datatype
integer
Maateenheden
- mmHg
Alias
- UMLS CUI [1,1]
- C0871470
- UMLS CUI [1,2]
- C0038846
- UMLS CUI [1,3]
- C0439568
Beschrijving
Diastolic blood pressure semi-supine
Datatype
integer
Maateenheden
- mmHg
Alias
- UMLS CUI [1,1]
- C0428883
- UMLS CUI [1,2]
- C0038846
- UMLS CUI [1,3]
- C0439568
Beschrijving
Systolic blood pressure standing
Datatype
integer
Maateenheden
- mmHg
Alias
- UMLS CUI [1,1]
- C0871470
- UMLS CUI [1,2]
- C0231472
- UMLS CUI [1,3]
- C0439568
Beschrijving
Diastolic blood pressure standing
Datatype
integer
Maateenheden
- mmHg
Alias
- UMLS CUI [1,1]
- C0428883
- UMLS CUI [1,2]
- C0231472
- UMLS CUI [1,3]
- C0439568
Beschrijving
Adverse Event - post dosing
Alias
- UMLS CUI-1
- C0877248
- UMLS CUI-2
- C0439568
Beschrijving
If Yes , please document on the Adverse Event Report Forms
Datatype
integer
Alias
- UMLS CUI [1,1]
- C0877248
- UMLS CUI [1,2]
- C0439574
Beschrijving
If Yes , please document on the Adverse Event Report Forms
Datatype
integer
Alias
- UMLS CUI [1,1]
- C0877248
- UMLS CUI [1,2]
- C1439442
Beschrijving
If Yes , please document on the Adverse Event Report Forms
Datatype
integer
Alias
- UMLS CUI [1,1]
- C0877248
- UMLS CUI [1,2]
- C1439477
Beschrijving
Pharmacokinetic sampling post dosing
Alias
- UMLS CUI-1
- C0031328
Beschrijving
Sample ID and specified time
Datatype
integer
Alias
- UMLS CUI [1,1]
- C1299222
- UMLS CUI [1,2]
- C1444698
Beschrijving
Actual time pharmacokinetics
Datatype
time
Alias
- UMLS CUI [1,1]
- C0031328
- UMLS CUI [1,2]
- C0040223
Beschrijving
Date sample
Datatype
date
Alias
- UMLS CUI [1,1]
- C0031328
- UMLS CUI [1,2]
- C1302413
Beschrijving
Discharge
Alias
- UMLS CUI-1
- C0030685
Beschrijving
Discharge Time
Datatype
time
Alias
- UMLS CUI [1]
- C3864299
Beschrijving
Advise the subject to refrain from consuming xanthine containing beverages and foods (Coffee, tea, cola beverages, cocoa chocolate), grapefruit containing products, quinine - containing products and food containing CYP1A2-inducing constituents (Brussel sprouts, broccoli, cabbage, etc ), from 24 h before the PK evaluation day, Periods 1 and 2 in Part B, until completion of assessments 24 h afterwards
Datatype
date
Alias
- UMLS CUI [1]
- C1545257
Similar models
PART B - Period 1 - Day 1 - Ropinirole and the effect of food in early stage Parkinson’s disease subjects 101468/164
C0244821 (UMLS CUI [1,2])
C1960468 (UMLS CUI [1,2])
C0700589 (UMLS CUI [1,3])
C3639483 (UMLS CUI [1,2])
C0244821 (UMLS CUI [1,2])
C3267134 (UMLS CUI [2])
C0678766 (UMLS CUI [1,2])
C1708968 (UMLS CUI [1,2])
C1708968 (UMLS CUI [1,2])
C1704258 (UMLS CUI [1,2])
C0035648 (UMLS CUI [2])
C0018939 (UMLS CUI [2])
C0022658 (UMLS CUI [3])
C0023895 (UMLS CUI [4])
C0014130 (UMLS CUI [5,1])
C0027765 (UMLS CUI [5,2])
C0007222 (UMLS CUI [6])
C0006826 (UMLS CUI [7])
C0522055 (UMLS CUI [2])
C0166049 (UMLS CUI [1,2])
C0019683 (UMLS CUI [2])
C1710477 (UMLS CUI [1,2])
C1167994 (UMLS CUI [1,3])
C1710477 (UMLS CUI [1,4])
C0451130 (UMLS CUI [2,1])
C1710477 (UMLS CUI [2,2])
C0039070 (UMLS CUI [2,1])
C0262926 (UMLS CUI [2,2])
C2129304 (UMLS CUI [1,2])
C0277883 (UMLS CUI [2])
C0023570 (UMLS CUI [1,2])
C3469597 (UMLS CUI [1,2])
C0262926 (UMLS CUI [1,3])
C3850068 (UMLS CUI [2])
C0282402 (UMLS CUI [3])
C3163616 (UMLS CUI [2])
C0244821 (UMLS CUI [1,2])
C0241889 (UMLS CUI [1,3])
C0559546 (UMLS CUI [1,4])
C0244821 (UMLS CUI [1,5])
C0241889 (UMLS CUI [1,6])
C0020517 (UMLS CUI [2,1])
C0244821 (UMLS CUI [2,2])
C0332119 (UMLS CUI [2,3])
C0559546 (UMLS CUI [3,1])
C0244821 (UMLS CUI [3,2])
C0332119 (UMLS CUI [3,3])
C0013227 (UMLS CUI [1,2])
C0085762 (UMLS CUI [1,2])
C2348568 (UMLS CUI [1,2])
C1321605 (UMLS CUI [1,3])
C0006147 (UMLS CUI [1,2])
C1708968 (UMLS CUI [1,2])
C1708968 (UMLS CUI [1,2])
C1704258 (UMLS CUI [1,2])
C0031809 (UMLS CUI [1,2])
C0678257 (UMLS CUI [1,3])
C0011008 (UMLS CUI [1,2])
C0040223 (UMLS CUI [1,2])
C0443288 (UMLS CUI [1,2])
C0202274 (UMLS CUI [1,2])
C0279996 (UMLS CUI [1,2])
C0005064 (UMLS CUI [1,2])
C1521902 (UMLS CUI [1,2])
C1095971 (UMLS CUI-2)
C0232117 (UMLS CUI-3)
C3812758 (UMLS CUI-4)
C3812758 (UMLS CUI [1,2])
C0038846 (UMLS CUI [1,2])
C3812758 (UMLS CUI [1,3])
C3812758 (UMLS CUI [1,2])
C0038846 (UMLS CUI [1,2])
C3812758 (UMLS CUI [1,3])
C0038846 (UMLS CUI [1,2])
C3812758 (UMLS CUI [1,3])
C0231472 (UMLS CUI [1,2])
C3812758 (UMLS CUI [1,3])
C3812758 (UMLS CUI [1,2])
C0442739 (UMLS CUI [1,2])
C1321605 (UMLS CUI [1,2])
C0013893 (UMLS CUI [1,2])
C1522541 (UMLS CUI [1,2])
C0521974 (UMLS CUI [1,2])
C0439659 (UMLS CUI [1,3])
C0521974 (UMLS CUI [1,2])
C0444930 (UMLS CUI [1,3])
C0205197 (UMLS CUI [1,2])
C0814440 (UMLS CUI [1,2])
C0205197 (UMLS CUI [1,3])
C0040223 (UMLS CUI [1,2])
C0001555 (UMLS CUI [1,2])
C0011008 (UMLS CUI [1,2])
C0001555 (UMLS CUI [1,2])
C0011008 (UMLS CUI [1,2])
C0232117 (UMLS CUI-2)
C0439568 (UMLS CUI-3)
C0040223 (UMLS CUI [1,2])
C0038846 (UMLS CUI [1,2])
C0439568 (UMLS CUI [1,3])
C0439568 (UMLS CUI [1,2])
C0038846 (UMLS CUI [1,2])
C0439568 (UMLS CUI [1,3])
C0038846 (UMLS CUI [1,2])
C0439568 (UMLS CUI [1,3])
C0231472 (UMLS CUI [1,2])
C0439568 (UMLS CUI [1,3])
C0231472 (UMLS CUI [1,2])
C0439568 (UMLS CUI [1,3])
C0439568 (UMLS CUI-2)
C0439574 (UMLS CUI [1,2])
C1439442 (UMLS CUI [1,2])
C1439477 (UMLS CUI [1,2])
C1444698 (UMLS CUI [1,2])
C0040223 (UMLS CUI [1,2])
C1302413 (UMLS CUI [1,2])