Aggressive non-Hodgkin's lymphoma (NHL)
Item
Histologically confirmed aggressive non-Hodgkin's lymphoma (NHL) by an excisional biopsy of a lymph node or an extensive biopsy of an extranodal involvement (if there is no lymph node involvement); CD20^+ B-cell lymphoma or CD20^- B-cell and T-cell lymphoma allowed
boolean
B-cell NHL
Item
B-cell NHL including the following: Stage III follicular lymphoma; Stage III follicular lymphoma and diffuse B-cell lymphoma; Lymphoblastic precursor B-cell lymphoma; Diffuse large cell B-cell lymphoma; Centroblastic; Immunoblastic; Plasmablastic; Anaplastic large cell; T-cell-rich B-cell lymphoma; Primary effusion lymphoma; Intravasal B-cell lymphoma; Primary mediastinal B-cell lymphoma; Mantle zone lymphoma, blastoid; Burkitt's lymphoma; Burkitt-like lymphoma; Aggressive marginal zone lymphoma (monocytoid)
boolean
T-cell NHL
Item
T-cell NHL including the following: Lymphoblastic precursor T-cell lymphoma; Peripheral T-cell lymphoma (PTCL) not otherwise specified (NOS); Lennert's lymphoma; T-zone lymphoma; T-cell lymphoma of the angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) type; Anaplastic large cell lymphoma; ALK^+ - ALK^-; Extranodal NK/T-cell lymphoma, nasal type; Intestinal T/NK-cell lymphoma (with or without enteropathy); Hepatosplenic gamma-delta lymphoma; Subcutaneous panniculitis-like PTCL; Aggressive T/NK PTCL; Anaplastic large-cell NHL, NOS
boolean
Bone marrow
Item
Bone marrow involvement no more than 25%
boolean
CNS / GI
Item
No lymphoma that is clearly restricted to the CNS or originating from the gastrointestinal tract
boolean
Age
Item
Age 61 to 80
boolean
Performance Status
Item
ECOG 0-2 OR - Karnofsky 60-100%
boolean
Hematopoietic
Item
WBC at least 2,500/mm^3; Platelet count at least 100,000/mm^3
boolean
Hepatic
Item
Bilirubin no greater than 2 times upper limit of normal (ULN); No active hepatitis infection
boolean
Renal
Item
Creatinine no greater than 2 times ULN
boolean
Cardiovascular
Item
No Canadian Cardiovascular Society class III or IV angina pectoris; No New York Heart Association class III or IV cardiac failure; Ejection fraction at least 50%; Fractional shortenings at least 25% by echocardiography or nuclear medicine examination
boolean
Pulmonary
Item
FEV1 at least 50%; Diffusion capacity at least 50%
boolean
Other
Item
No uncontrolled diabetes mellitus; No known hypersensitivity to any study medications; No other concurrent malignancy; HIV negative
boolean
Prior concurrent therapy
Item
No prior chemotherapy; No prior radiotherapy; Must not have already initiated lymphoma therapy (except for the prephase treatment specified for this study); No other concurrent lymphoma therapy; No concurrent participation in another treatment study
boolean
Diagnosis
Item
Diagnosis
string
C0011900 (UMLS CUI)
439401001 (SNOMED CT 2010_0731)
Diagnostic Neoplasm Staging
Item
Diagnostic Neoplasm Staging
string
C0027646 (UMLS CUI)
Bone Marrow Involvement
Item
Bone Marrow Involvement
string
C1517677 (UMLS CUI)
Age
Item
Age
string
C0001779 (UMLS CUI)
102518004 (SNOMED CT 2010_0731)
ECOG performance status
Item
ECOG performance status
string
423740007 (SNOMED CT 2010_0731)
Karnofsky performance status
Item
Karnofsky performance status
string
273546003 (SNOMED CT 2010_0731)
WBC
Item
White blood cell count
string
767002 (SNOMED CT 2010_0731)
6690-2 (LOINC)
Platelet count - finding (Code )
Item
Platelet count - finding
string
365632008 (SNOMED CT 2010_0731)
C1287267 (UMLS CUI)
777-3 (LOINC)
Bilirubin
Item
Bilirubin
string
79706000 (SNOMED CT 2010_0731)
C0011221 (UMLS CUI)
1975-2 (LOINC)
Hepatitis
Item
Hepatitis
string
29001004 (SNOMED CT 2010_0731)
C0019158 (UMLS CUI)
Creatinine
Item
Creatinine
string
C0010294 (UMLS CUI)
15373003 (SNOMED CT 2010_0731)
38483-4 (LOINC)
10011358 (MedDRA 13.1)
Canadian Cardiovascular Society classification of angina (Code )
Item
Canadian Cardiovascular Society classification of angina
string
C1277207 (UMLS CUI)
134438001 (SNOMED CT 2010_0731)
New York Heart Association Classification
Item
NYHA class
string
C1275491 (UMLS CUI)
420816009 (SNOMED CT 2010_0731)
Cardiac ejection fraction
Item
Ejection fraction
string
C0232174 (UMLS CUI)
70822001 (SNOMED CT 2010_0731)
Forced expired volume in one second/vital capacity ratio
Item
FEV1/VC ratio
string
C0429744 (UMLS CUI)
251943006 (SNOMED CT 2010_0731)
Diffusion capacity of lung
Item
Diffusion capacity
string
C0231971 (UMLS CUI)
54715006 (SNOMED CT 2010_0731)
Diabetes mellitus
Item
Diabetes mellitus
string
C0011849 (UMLS CUI)
191044006 (SNOMED CT 2010_0731)
Allergic reaction, due to correct medicinal substance properly administered
Item
Hypersensitivity to medication
string
C0274302 (UMLS CUI)
57302007 (SNOMED CT 2010_0731)
HIV negative
Item
HIV negative
string
C0481430 (UMLS CUI)
143223008 (SNOMED CT 2010_0731)
Chemotherapy
Item
Chemotherapy
string
C0392920 (UMLS CUI)
150415003 (SNOMED CT 2010_0731)
Radiotherapy
Item
Radiotherapy
string
C1522449 (UMLS CUI)
302505005 (SNOMED CT 2010_0731)
Enrollment
Item
Enrollment
string
C1516879 (UMLS CUI)
Therapeutic procedure
Item
Therapeutic procedure
string
C0087111 (UMLS CUI)