ID
4465
Descripción
Combination Chemotherapy With or Without Rituximab in Treating Older Patients With Non-Hodgkin's Lymphoma DISEASE CHARACTERISTICS: - Histologically confirmed aggressive non-Hodgkin's lymphoma (NHL) by an excisional biopsy of a lymph node or an extensive biopsy of an extranodal involvement (if there is no lymph node involvement) - CD20^+ B-cell lymphoma or CD20^- B-cell and T-cell lymphoma allowed - B-cell NHL including the following: Stage III follicular lymphoma; Stage III follicular lymphoma and diffuse B-cell lymphoma; Lymphoblastic precursor B-cell lymphoma; Diffuse large cell B-cell lymphoma; Centroblastic; Immunoblastic; Plasmablastic; Anaplastic large cell; T-cell-rich B-cell lymphoma; Primary effusion lymphoma; Intravasal B-cell lymphoma; Primary mediastinal B-cell lymphoma; Mantle zone lymphoma, blastoid; Burkitt's lymphoma; Burkitt-like lymphoma; Aggressive marginal zone lymphoma (monocytoid); - T-cell NHL including the following: Lymphoblastic precursor T-cell lymphoma; Peripheral T-cell lymphoma (PTCL) not otherwise specified (NOS); Lennert's lymphoma; T-zone lymphoma; T-cell lymphoma of the angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) type; Anaplastic large cell lymphoma; ALK^+ - ALK^-; Extranodal NK/T-cell lymphoma, nasal type; Intestinal T/NK-cell lymphoma (with or without enteropathy); Hepatosplenic gamma-delta lymphoma; Subcutaneous panniculitis-like PTCL; Aggressive T/NK PTCL; Anaplastic large-cell NHL, NOS - Bone marrow involvement no more than 25% - No lymphoma that is clearly restricted to the CNS or originating from the gastrointestinal tract PATIENT CHARACTERISTICS: Age - 61 to 80 Performance status - ECOG 0-2 OR - Karnofsky 60-100% Life expectancy - Not specified Hematopoietic - WBC at least 2,500/mm^3; Platelet count at least 100,000/mm^3 Hepatic - Bilirubin no greater than 2 times upper limit of normal (ULN); No active hepatitis infection Renal - Creatinine no greater than 2 times ULN Cardiovascular - No Canadian Cardiovascular Society class III or IV angina pectoris - No New York Heart Association class III or IV cardiac failure - Ejection fraction at least 50% - Fractional shortenings at least 25% by echocardiography or nuclear medicine examination Pulmonary - FEV1 at least 50% - Diffusion capacity at least 50% Other - No uncontrolled diabetes mellitus - No known hypersensitivity to any study medications - No other concurrent malignancy - HIV negative PRIOR CONCURRENT THERAPY: Biologic therapy - Not specified Chemotherapy - No prior chemotherapy Endocrine therapy - Not specified Radiotherapy - No prior radiotherapy Surgery - Not specified Other - Must not have already initiated lymphoma therapy (except for the prephase treatment specified for this study) - No other concurrent lymphoma therapy - No concurrent participation in another treatment study
Palabras clave
Versiones (2)
- 9/12/13 9/12/13 - Martin Dugas
- 22/12/14 22/12/14 - Martin Dugas
Subido en
9 de diciembre de 2013
DOI
Para solicitar uno, por favor iniciar sesión.
Licencia
Creative Commons BY-NC 3.0 Legacy
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Eligibility NCT00052936 NHL
Eligibility
- StudyEvent: Eligibility
Descripción
Patient characteristics and prior concurrent therapy
Descripción
Age
Tipo de datos
boolean
Descripción
Performance Status
Tipo de datos
boolean
Descripción
Hematopoietic
Tipo de datos
boolean
Descripción
Hepatic
Tipo de datos
boolean
Descripción
Renal
Tipo de datos
boolean
Descripción
Cardiovascular
Tipo de datos
boolean
Descripción
Pulmonary
Tipo de datos
boolean
Descripción
Other
Tipo de datos
boolean
Descripción
Prior concurrent therapy
Tipo de datos
boolean
Descripción
Medical Concepts
Descripción
Diagnosis
Tipo de datos
string
Alias
- UMLS CUI
- C0011900
- SNOMED CT 2010_0731
- 439401001
Descripción
Diagnostic Neoplasm Staging
Tipo de datos
string
Alias
- UMLS CUI
- C0027646
Descripción
Bone Marrow Involvement
Tipo de datos
string
Alias
- UMLS CUI
- C1517677
Descripción
Age
Tipo de datos
string
Alias
- UMLS CUI
- C0001779
- SNOMED CT 2010_0731
- 102518004
Descripción
ECOG performance status
Tipo de datos
string
Alias
- SNOMED CT 2010_0731
- 423740007
Descripción
Karnofsky performance status
Tipo de datos
string
Alias
- SNOMED CT 2010_0731
- 273546003
Descripción
WBC
Tipo de datos
string
Alias
- SNOMED CT 2010_0731
- 767002
- LOINC
- 6690-2
Descripción
Platelet count - finding (Code )
Tipo de datos
string
Alias
- SNOMED CT 2010_0731
- 365632008
- UMLS CUI
- C1287267
- LOINC
- 777-3
Descripción
Bilirubin
Tipo de datos
string
Alias
- SNOMED CT 2010_0731
- 79706000
- UMLS CUI
- C0011221
- LOINC
- 1975-2
Descripción
Hepatitis
Tipo de datos
string
Alias
- SNOMED CT 2010_0731
- 29001004
- UMLS CUI
- C0019158
Descripción
Creatinine
Tipo de datos
string
Alias
- UMLS CUI
- C0010294
- SNOMED CT 2010_0731
- 15373003
- LOINC
- 38483-4
- MedDRA 13.1
- 10011358
Descripción
Canadian Cardiovascular Society classification of angina (Code )
Tipo de datos
string
Alias
- UMLS CUI
- C1277207
- SNOMED CT 2010_0731
- 134438001
Descripción
New York Heart Association Classification
Tipo de datos
string
Alias
- UMLS CUI
- C1275491
- SNOMED CT 2010_0731
- 420816009
Descripción
Cardiac ejection fraction
Tipo de datos
string
Alias
- UMLS CUI
- C0232174
- SNOMED CT 2010_0731
- 70822001
Descripción
Forced expired volume in one second/vital capacity ratio
Tipo de datos
string
Alias
- UMLS CUI
- C0429744
- SNOMED CT 2010_0731
- 251943006
Descripción
Diffusion capacity of lung
Tipo de datos
string
Alias
- UMLS CUI
- C0231971
- SNOMED CT 2010_0731
- 54715006
Descripción
Diabetes mellitus
Tipo de datos
string
Alias
- UMLS CUI
- C0011849
- SNOMED CT 2010_0731
- 191044006
Descripción
Allergic reaction, due to correct medicinal substance properly administered
Tipo de datos
string
Alias
- UMLS CUI
- C0274302
- SNOMED CT 2010_0731
- 57302007
Descripción
HIV negative
Tipo de datos
string
Alias
- UMLS CUI
- C0481430
- SNOMED CT 2010_0731
- 143223008
Descripción
Chemotherapy
Tipo de datos
string
Alias
- UMLS CUI
- C0392920
- SNOMED CT 2010_0731
- 150415003
Descripción
Radiotherapy
Tipo de datos
string
Alias
- UMLS CUI
- C1522449
- SNOMED CT 2010_0731
- 302505005
Descripción
Enrollment
Tipo de datos
string
Alias
- UMLS CUI
- C1516879
Descripción
Therapeutic procedure
Tipo de datos
string
Alias
- UMLS CUI
- C0087111
Similar models
Eligibility
- StudyEvent: Eligibility
439401001 (SNOMED CT 2010_0731)
102518004 (SNOMED CT 2010_0731)
C0019158 (UMLS CUI)
134438001 (SNOMED CT 2010_0731)
420816009 (SNOMED CT 2010_0731)
70822001 (SNOMED CT 2010_0731)
251943006 (SNOMED CT 2010_0731)
54715006 (SNOMED CT 2010_0731)
191044006 (SNOMED CT 2010_0731)
57302007 (SNOMED CT 2010_0731)
143223008 (SNOMED CT 2010_0731)
150415003 (SNOMED CT 2010_0731)
302505005 (SNOMED CT 2010_0731)