ID

44718

Description

The purpose of this Phase II study is to determine if AZD4877, an experimental drug that is a novel anti-mitotic agent (Eg5 or Kinesin Spindle Protein inhibitor that interferes with tumor cell division leading to tumor growth), can reduce tumor sizes in patients with bladder cancer see http://clinicaltrials.gov/ct2/show/study/NCT00661609

Lien

http://clinicaltrials.gov/ct2/show/study/NCT00661609

Mots-clés

Versions (4)
  1. 21/11/2011 21/11/2011 -
  2. 27/03/2014 27/03/2014 - Martin Dugas
  3. 17/09/2021 17/09/2021 -
  4. 27/09/2021 27/09/2021 - Sarah Riepenhausen
Détendeur de droits

AstraZeneca

Téléchargé le

27 septembre 2021

DOI

Pour une demande vous connecter.

Licence

Creative Commons BY 4.0
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A Phase II Study of AZD4877 (a Novel Anti-mitotic DRKS00004052

Anglais

Eligibility Bladder Cancer NCT00661609

1 Formulaires  
Inclusion criteria
Description

Inclusion criteria

Alias
UMLS CUI [1]
C1512693
Confirmed urothelial cancer (cancer of the bladder, renal pelvis, ureter, or urethra).
Description

Urothelial cancer

Type de données

boolean

Alias
UMLS CUI [1]
C1519840
Tumor, Node, Metastasis (TNM) Stage IV urothelial cancer that can not be helped by curative surgery and/or curative radiotherapy
Description

Stage IV

Type de données

boolean

Alias
UMLS CUI-1
C0441772
Must have had a maximum of 2 prior chemotherapeutic regimens, one for unremovable and/or metastasized disease, and the other in the adjuvant or neo-adjuvant setting.
Description

Prior chemotherapy

Type de données

boolean

Alias
UMLS CUI-1
C1514457
Ambulatory and capable of all selfcare more than 50% of waking hours
Description

Selfcare

Type de données

boolean

Alias
UMLS CUI-1
C0036592
Exclusion criteria
Description

Exclusion criteria

Alias
UMLS CUI [1]
C0680251
Prior treatment with investigational or standard anti-cancer agents, including radiotherapy, within 4 weeks prior to first dose of study medication; 6 weeks if prior systemic mitomycin, nitrosourea, or suramin.
Description

Prior treatment

Type de données

boolean

Alias
UMLS CUI-1
C1514463
Inadequate bone marrow reserve
Description

Bone marrow

Type de données

boolean

Alias
UMLS CUI-1
C0005953
Inadequate liver function in the presence of liver metastases
Description

Liver function

Type de données

boolean

Alias
UMLS CUI
C0232744
Impaired renal function
Description

Renal function

Type de données

boolean

Alias
UMLS CUI
C1565489
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Similar models

Eligibility Bladder Cancer NCT00661609

1 Formulaires
Name
Type
Description | Question | Decode (Coded Value)
Type de données
Alias
Item Group
Inclusion criteria
C1512693 (UMLS CUI [1])
Urothelial cancer
Item
Confirmed urothelial cancer (cancer of the bladder, renal pelvis, ureter, or urethra).
boolean
C1519840 (UMLS CUI [1])
Stage IV
Item
Tumor, Node, Metastasis (TNM) Stage IV urothelial cancer that can not be helped by curative surgery and/or curative radiotherapy
boolean
C0441772 (UMLS CUI-1)
Prior chemotherapy
Item
Must have had a maximum of 2 prior chemotherapeutic regimens, one for unremovable and/or metastasized disease, and the other in the adjuvant or neo-adjuvant setting.
boolean
C1514457 (UMLS CUI-1)
Selfcare
Item
Ambulatory and capable of all selfcare more than 50% of waking hours
boolean
C0036592 (UMLS CUI-1)
Item Group
Exclusion criteria
C0680251 (UMLS CUI [1])
Prior treatment
Item
Prior treatment with investigational or standard anti-cancer agents, including radiotherapy, within 4 weeks prior to first dose of study medication; 6 weeks if prior systemic mitomycin, nitrosourea, or suramin.
boolean
C1514463 (UMLS CUI-1)
Bone marrow
Item
Inadequate bone marrow reserve
boolean
C0005953 (UMLS CUI-1)
Liver function
Item
Inadequate liver function in the presence of liver metastases
boolean
C0232744 (UMLS CUI)
Renal function
Item
Impaired renal function
boolean
C1565489 (UMLS CUI)
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